Biomarkers: Impact on Treatment Choices and Future Expectations
The key opinion leaders share their strategies for selecting systemic therapy, comparing immunotherapy combination (IO/IO) versus immunotherapy plus tyrosine kinase inhibitor (IO/TKI) approaches, for previously untreated patients with advanced renal cell carcinoma.
- Dr McKay and Campbell: Please discuss your treatment approach to systemic therapy (IO/IO vs. IO/TKI) for treatment-naïve patients with advanced RCC.
- How do the most recent data updates for CM-214, CLEAR, KN-426, and CM-9ER impact your treatment decisions?
- Please discuss the importance of biomarkers in determining appropriate treatment options.
- CLEAR – biomarker analysis (Choueiri, TK, et al. 2024 ASCO Annual Meeting. Abstract 4504).
- CheckMate -214 – biomarker analysis (Matar, S, et al 2024 ASCO Annual Meeting. Abstract 4536).
- Keynote-426 – biomarker analysis (Rini BI, et al. 2024 ASCO Annual Meeting. Abstract 4505).
- Do you have a “go-to” treatment?
- How do you factor OS, PFS, and DOR into your decision-making?
- Does it differ for those with intermediate/poor risk vs. favorable risk disease?
- If so, what patient-specific variables would cause you to re-evaluate your treatment choice(s)?
- Age? Tumor burden? Kidney function? Performance status? Chronic comorbidities?
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