Review of CLEAR and CheckMate-9ER: Four-Year and 55 Month Follow-Up Data
Matthew Campbell, MD, MS, analyzes the crucial efficacy and safety results from the CLEAR trial's 4-year final analysis, incorporating insights on how these findings influence clinical decision-making for treatment-naïve patients with advanced renal cell carcinoma.
EP: 1.Current treatment options for ccRCC based on patient and disease factors
EP: 2.CheckMate-214: Long-term follow-up data
EP: 3.Review of CheckMate-214: Long-term follow-up in favorable risk subgroup
EP: 4.Review of CLEAR and CheckMate-9ER: Four-Year and 55 Month Follow-Up Data
EP: 5.Review of KEYNOTE-426: Five-year Follow-up Data
EP: 6.Discontinuation or Continuation of IO Therapy – IO/IO vs. IO/TKI Regimens
EP: 7.Treatment-free survival in IO/TKI
EP: 8.Biomarkers: Impact on Treatment Choices and Future Expectations
EP: 9.Management of Adverse Events – IO/IO and IO/TKI
EP: 10.New formulations for current therapies – SC vs. IV
EP: 11.Novel Agents/Combinations for aRCC
- Dr Campbell: Please briefly review key efficacy and safety data from the CLEAR trial 4-year final analysis (Motzer et al. J Clin Oncol. 2024),
- What are the clinical implications of these data for treatment-naïve patients with advanced RCC?
- In responders, how important is the durability of the response (OS) based on the original response (CR, PR with ≥75% reduction, PR with ≥30% to <75% reduction) for both the intermediate/poor and favorable-risk group?
Enhancing Precision in Immunotherapy: CD8 PET-Avidity in RCC
March 1st 2024In this episode of Emerging Experts, Peter Zang, MD, highlights research on baseline CD8 lymph node avidity with 89-Zr-crefmirlimab for the treatment of patients with metastatic renal cell carcinoma and response to immunotherapy.
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Beyond the First-Line: Economides on Advancing Therapies in RCC
February 1st 2024In our 4th episode of Emerging Experts, Minas P. Economides, MD, unveils the challenges and opportunities for renal cell carcinoma treatment, focusing on the lack of therapies available in the second-line setting.
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Belzutifan Demonstrates Superior PFS, ORR vs Everolimus in Advanced RCC
August 23rd 2024LITESPARK-005 showed that belzutifan improved progression-free survival and objective response vs everolimus in patients with advanced clear cell renal cell carcinoma previously treated with immune checkpoint and antiangiogenic therapies.
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Ornstein Discusses TKI Dose Interruption and Discontinuation in Combination RCC Therapy
August 19th 2024During a Case-Based Roundtable® event, Moshe Ornstein, MD, MA, discussed dose modification approaches for patients receiving combination immunotherapy/tyrosine kinase inhibitor therapy for advanced renal cell carcinoma.
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