Mesa Provides Tips for Treating Myelofibrosis After Ruxolitinib
September 17th 2016According to Ruben A. Mesa, MD, developing a treatment plan for myelofibrosis (MF) patients who fail ruxolitinib requires an understanding of both current treatment options and those that are expected to become available within the next several years.
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Immunotherapy May Be Next Frontier for AML, Says Daver
September 16th 2016Immunotherapy offers promise in acute myeloid leukemia (AML), a disease type which has not seen significant progress in many years, said Naval G. Daver, MD, Assistant Professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center.
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Molecular, Genetic Studies Provide New Insights Into MDS/MPN
September 16th 2016As molecular and genetic studies have provided new insights into myelodysplastic and myeloproliferative neoplasms (MDS/MPN), diagnostic criteria and therapeutic strategies for the diseases continue to evolve.
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Majority of Study Patients With Relapsed Light Chain Amyloidosis Responded to Daratumumab
September 13th 2016According to a small study reported at the 2016 Society of Hematologic Oncology annual meeting, almost 90% of patients with previously treated light chain amyloidosis responded to single-agent daratumumab (Darzalex).
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An Overview of the MA17R Trial in Breast Cancer
July 29th 2016Frankie Ann Holmes, MD, medical oncologist, Texas Oncology, discusses the implications of the results of the MA17R trial, which is a randomized phase III clinical trial that examined the benefits of extending aromatase inhibitors with letrozole as a treatment for postmenopausal patients with early breast cancer.
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CDK4/6 Inhibitors Expanding Treatment Options for ER+ Metastatic Breast Cancer
July 24th 2016More options are now available for combining and sequencing therapy for patients with estrogen (ER)–positive metastatic breast cancer (mBC), including the deployment of CDK4/6 inhibitors, as clinicians endeavor to individualize the sequencing of therapies to improve patient outcomes, according to Maura N. Dickler, MD.
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Neoadjuvant Studies Identifying Optimal Strategies for TNBC
July 23rd 2016A better understanding of how patients with triple-negative breast cancer respond to neoadjuvant therapy regimens is helping to further individualize therapy for patients while also informing treatment decisions in the adjuvant setting.
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Crowdsourcing Tumor Samples Could Advance Metastatic Breast Cancer Treatments
June 17th 2016A new nationwide research project is encouraging patients to share tumor samples and clinical information with researchers in the hope that it will lead to discoveries for new and improved treatment options and, ultimately, a cure, for metastatic breast cancer.
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Utomilumab/Pembrolizumab Combo Shows Responses in Different Solid Tumors
June 15th 2016Adding utomilumab (PF-05082566), a 4-1BB agonist, to pembrolizumab (Keytruda), a PD-1 inhibitor, was shown to be a safe and effective combination therapy for patients with different types of advanced solid tumors, according to findings from a phase Ib study presented at the 2016 ASCO Annual Meeting.
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New Immunotherapy Agent Reduces Disease Progression Risk in Gastric Cancers
June 15th 2016Findings for the new immunotherapy agent targeting claudin18.2 (CLDN18.2) presented at the 2016 ASCO Annual Meeting raised the possibility of a new therapeutic agent in a tumor type with relatively few current options. When added to standard chemotherapy, the treatment reduced the risk of death or disease progression by approximately 50% for patients with CLDN18.2-positive advanced gastric cancers.
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