Sonja Althammer Discusses Biomarkers for Durvalumab in Lung Cancer
November 13th 2016Sonja Althammer, PhD, Team Leader Bioinformatics at Definiens, discusses a study looking to define a subgroup of patients with non–small cell lung cancer who respond best to treatment with the PD-L1 inhibitor durvalumab.
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TRC105 Plus Pazopanib Shows Promise in Advanced Angiosarcoma
November 13th 2016TRC105, an endoglin antibody, combined with pazopanib showed promising anti-tumor activity in patients with advanced angiosarcoma, warranting the initiation of a phase III study to explore the combination further.<br />
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Radiomics Could Play Important Predictive Role in Patient Outcomes in Sarcoma
November 12th 2016Though surgical resection and radiation therapy remain at the forefront of the treatment for localized disease, accurately predicting outcomes for individual patients remains a challenge, which radiomics, an emerging research field, hopes to alleviate.
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Model Suggests Olaratumab May Be Effective in Pediatric Sarcoma
November 12th 2016Olaratumab displayed anti-tumor activity both as a single-agent and in concert with standard of care chemotherapy in a study using human pediatric sarcoma cell-derived models and in human sarcoma cell transfected mice.
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The CheckPoints Let Immunotherapy Experts Cut Loose
November 12th 2016The CheckPoints, which are considered the official house band of the Society for Immunotherapy of Cancer (SITC), performs every year at the annual meeting, as well as at a SITC sponsored event at the ASCO annual meeting each year.
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Novel Immune Checkpoint Identified as Promising Target for Blockade Strategies
November 12th 2016A new immune checkpoint called PVRIG has emerged as a ripe target for anticancer therapy in solid tumors and an antibody that blocks its ability to suppress an antitumor response is in development.<br />
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Pembrolizumab Plus Cyclophosphamide Shows Limited Benefit in Diverse Types of Sarcoma
November 12th 2016Pembrolizumab plus low dose metronomic cyclophosphamide demonstrated limited patient benefit in adult patients with diverse types of unresectable locally advanced or metastatic sarcoma.<br />
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Dual Biomarker Signature Correlates With Outcomes to Anti-PD-L1 Therapy
November 12th 2016The presence of both PD-L1–positive and CD8+ cells may help to predict response in patients with non–small cell lung cancer (NSCLC) treated with durvalumab (MEDI4736), according to findings presented during a late-breaking abstract session at the <em>SITC 31st Annual Meeting & Associated Programs</em>. Sonja Althammer, PhD, presented on the correlation between improved survival rates to durvalumab treatment and high CD8+ and PD-L1+ cell densities.
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Nivolumab/Pazopanib Combo Shows Promise in Relapsed Sarcoma
November 12th 2016Clinical benefit, including partial response and stable disease, was observed in 11 of 20 patients with relapsed metastatic sarcoma following nivolumab treatment that was administered either alone or in combination with pazopanib.
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Current and Emerging Immunotherapeutic Strategies in Melanoma
November 12th 2016Omid Hamid, MD, chief, Translational Research and Immunotherapy, director, Melanoma Therapeutics, discusses current and emerging immunotherapeutic strategies in the field of melanoma during an interview at the 34th Annual Chemotherapy Foundation Symposium<sup>TM</sup>.
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Expert Discusses Pembrolizumab Potential in Sarcoma
November 12th 2016Updated results of the multicenter phase II study SARC028 demonstrate both a favorable safety profile as well as encouraging efficacy for the use pembrolizumab (Keytruda) as a treatment for patients with advanced sarcomas.
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Anticipated METRIC Results Could Lead to First Targeted Agent Approved in TNBC
November 12th 2016Findings from a highly anticipated, randomized, phase II trial could possibly pave the path for the FDA approval of the first targeted therapy for patients with triple-negative breast cancer (TNBC), explains Linda T. Vahdat, MD.<br />
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Pembrolizumab Demonstrates Anti-Tumor Activity in Sarcoma Subtypes
November 11th 2016Treatment with pembrolizumab, an immunotherapeutic agent approved in melanoma, lung, and head and neck cancer, and which is undergoing investigation in several other cancer types, reduced the size of tumors in patients with a specific soft tissue sarcoma.
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Risk of Local Recurrence Varies Across Sarcoma Histotypes With Adjuvant/Neoadjuvant Therapy
November 11th 2016Adjuvant chemotherapy was found to decrease the rates of local recurrence in some subtypes of extremity soft tissue sarcoma; however, the use of adjuvant/neoadjuvant therapy did not impact overall survival.
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Current Progress and Future With Glembatumumab Vedotin in TNBC
November 11th 2016Linda T. Vahdat, MD, PhD, ‎Breast Cancer Research Program Leader at Meyer Cancer Center, Weill Cornell Medicine and NewYork-Presbyterian, discusses the current progress being made with glembatumumab vedotin in triple-negative breast cancer (TNBC) and what the future holds for this agent.
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Expert Highlights Factors Influencing Local Control in Ewing Sarcoma
November 11th 2016 <br /> Local recurrence is associated with very poor prognosis in patients with Ewing sarcoma. Researchers are seeking to identify the factors associated with local recurrence in patients undergoing multimodal treatment.
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Optimizing Neadjuvant Chemotherapy in Ovarian Cancer Depends on Patient Selection
November 11th 2016The use of neoadjuvant chemotherapy for the treatment of advanced ovarian cancer has risen dramatically in recent years, improving quality of life for patients and reducing morbidity, but challenges remain for oncologists looking to deploy this treatment approach in clinical practice.
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Evolving NCCN Guidelines for MPNs
November 10th 2016Ruben A. Mesa, MD, chair, Division of Hematology and Medical Oncology, deputy director, professor of Medicine, Mayo Clinic, discusses the NCCN Clinical Practice Guidelines for myeloproliferative neoplasms (MPNs) and who the recommendations will transition over the next year. Mesa spoke on the topic during an interview at the 34th Annual Chemotherapy Foundation Symposium™, held November 9-11, 2016 in New York City.
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