September 20th 2024
The approval of amivantamab plus carboplatin and pemetrexed is supported by data from the phase 3 MARIPOSA-2 trial.
42nd Annual CFS: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Annual Hawaii Cancer Conference
January 25-26, 2025
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
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Differentiating Adverse Events for Antibody-Drug Conjugates Across Solid Tumor Management
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Co-Clinical Trial of Olaparib and Temozolomide in SCLC PDX Models
April 18th 2018Benjamin J. Drapkin, MD, PhD, clinical fellow in medicine, Dana-Farber Cancer Institute, resident, Massachusetts General Hospital, discusses the co-clinical trial of olaparib (Lynparza) and temozolomide (temodar) in small cell lung cancer (SCLC) patient-derived xenografts (PDX) models during the 2018 AACR Annual Meeting.
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Mutation Burden Predictive of First-Line Immunotherapy Response in NSCLC
April 18th 2018In an updated analysis of CheckMate-586, investigators found that tumor mutational burden identified patients with non–small cell lung cancer who were more likely to respond to first-line combination immunotherapy with nivolumab and ipilimumab.
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Nivolumab/Ipilimumab Significantly Improves PFS in TMB-High NSCLC
April 17th 2018The 1-year progression-free survival rate was more than tripled with the combination of nivolumab and ipilimumab versus chemotherapy in treatment-naïve patients with non–small cell lung cancer with high tumor mutation burden, according to initial findings from the phase III CheckMate-227 trial.
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Neoadjuvant Nivolumab Demonstrates Promising Pathologic Response Rate in Resectable NSCLC
April 17th 2018According to results of a pilot study presented at the 2018 AACR Annual Meeting and simultaneously published in the <em>New England Journal of Medicine,</em> neoadjuvant treatment with the PD-1 inhibitor nivolumab (Opdivo) demonstrated a 45% major pathologic response rate in patients with resectable stage I to III non–small cell lung cancer (NSCLC) irrespective of PD-L1 expression.
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Survival Significantly Improved With Frontline Pembrolizumab Combination in NSCLC
April 17th 2018Results from the phase III KEYNOTE-189 trial were presented at the 2018 AACR Annual Meeting, indicating that the combination of pembrolizumab with standard chemotherapy in the frontline setting reduced the risk of death by more than 50% in patients with nonsquamous non-small cell lung cancer without <em>EGFR </em>or <em>ALK</em> mutations.
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Patient-Reported Outcomes for Alectinib in NSCLC Confirm Benefit Seen in ALEX Trial
April 16th 2018Findings from the phase III ALEX trial were consistent with earlier results on efficacy and adverse events. Investigators said there were superior patient-reported outcomes for the next-generation tyrosine kinase inhibitor (TKI) alectinib (Alecensa) compared to the standard of care TKI inhibitor crizotinib (Xalkori) for patients with ALK-positive non–small cell lung cancer.
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BLU-667 Demonstrates Broad Activity in RET+ Advanced Solid Tumors
April 16th 2018According to the results from a phase I study, BLU-667, a next-generation tyrosine kinase inhibitor, was well-tolerated and demonstrated clinical benefit in patients with advanced, <em>RET</em>-altered solid tumors who had progressed on previous therapies. These findings were presented April 14 to 18 at the ASCR Annual Meeting 2018 in Chicago, Illinois.
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Improved QOL With First-Line Osimertinib Compared With Standard of Care in EGFR+ NSCLC
April 13th 2018Similar improvements in quality of life were found with frontline treatment of osimertinib for patients with advanced EGFR-mutant non–small cell lung cancer, as well as a clinically meaningful improvement in cough, compared with the standard-of-care EGFR TKIs, according to the phase III FLAURA trial. The results were presented at the 2018 European Lung Cancer Congress in Geneva, Switzerland.
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Upfront Atezolizumab Combination Pushes Ahead as Promising New Regimen in NSCLC
April 13th 2018According to findings presented by Martin Reck, MD, PhD, at the 2018 European Lung Cancer Conference, the frontline regimen of atezolizumab, bevacizumab, carboplatin, and paclitaxel has became a potential new standard of care for the treatment of patients with metastatic nonsquamous non–small cell lung cancer.
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Updated Atezolizumab Findings Confirm Long-Term Survival Exists in Lung Cancer, Expert Says
April 12th 2018According to 3-year survival findings from the phase II POPLAR study, anti PD-L1 immunotherapy with atezolizumab (Tecentriq) demonstrated strong superiority to docetaxel in locally advanced or metastatic non–small cell lung cancer.
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Frontline Pembrolizumab Improves Survival in NSCLC With Lower Level of PD-L1 Expression
April 12th 2018Overall survival was improved with the PD-1 inhibitor pembrolizumab versus chemotherapy as a frontline treatment for patients with locally advanced or metastatic non–small cell lung cancer and a PD-L1 expression level ≥1%, according to findings from the phase III KEYNOTE-042 trial.<br />
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