November 14th 2024
A new BLA for datopotamab deruxtecan aims for FDA accelerated approval to treat EGFR-mutated NSCLC based on data from multiple TROPION trials, following FDA feedback.
42nd Annual CFS: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Annual Hawaii Cancer Conference
January 25-26, 2025
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
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Differentiating Adverse Events for Antibody-Drug Conjugates Across Solid Tumor Management
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How the Treatment Paradigm for EGFR+ Lung Cancer Will Transform
November 27th 2017Justin F. Gainor, MD, medical oncologist, Assistant Professor of Medicine, Massachusetts General Hospital, Harvard Medical School, discusses how the treatment paradigm for EGFR+ lung cancer will transform over the next several years.
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New Results Uphold Frontline Osimertinib Benefit Against CNS Mets in NSCLC
November 22nd 2017In data presented at the 2017 ESMO Asia Congress, updated results again sustained the benefit of frontline osimertinib (Tagrisso) in patients with <em>EGFR</em>-positive advanced non–small cell lung cancer (NSCLC) and CNS metastases at baseline.
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Ahead of NSCLC Approval Decision, FDA Now Weighing Durvalumab Data in NEJM
November 22nd 2017After granting a priority review to durvalumab (Imfinzi) in October for the treatment of patients with stage III, unresectable NSCLC whose disease has not progressed following platinum-based chemoradiation, the FDA is now reviewing results from the phase III PACIFIC trial, which have now been published in the print edition of the New England Journal Medicine.
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IMpower150 Trial Delays Progression in Advanced NSCLC With Atezolizumab/Bevacizumab Combo
November 21st 2017In topline results announced from the phase III IMpower150 trial, atezolizumab (Tecentriq) in combination with bevacizumab (Avastin) and chemotherapy delayed progression or death when compared with bevacizumab and chemotherapy alone for patients with advanced nonsquamous non–small cell lung cancer.
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Emerging Treatment Strategies for Nonsquamous Non-Small Cell Lung Cancer
November 21st 2017Although great advances have been made in the treatment of advanced, metastatic, and nonresectable, nonsquamous, non–small cell lung cancer (NSCLC), prognosis remains relatively poor, and recurrence is common. Howard Jack West, MD, medical director of the Thoracic Oncology Program at Swedish Cancer Institute, Seattle, Washington, explained in an abstract that “platinum-based chemotherapy is the current standard of care for patients with newly diagnosed advanced nonsquamous NSCLC.
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Experts within the lung cancer community are eagerly anticipating the phase III findings of the KEYNOTE-189 trial, and they are hopeful that the combination of pembrolizumab (Keytruda) plus carboplatin and pemetrexed (Alimta) will demonstrate an overall survival advantage in patients with nonsquamous non–small cell lung cancer.
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Diagnosis, Staging, and Testing for Nonsquamous NSCLC
November 21st 2017Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 80% to 85% of lung cancer cases, whereas small cell lung cancer (SCLC) comprises approximately 10% to 15% of lung cancer cases.
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Current Treatment Strategies in Nonsquamous Non-Small Cell Lung Cancer
November 21st 2017Nonsquamous non‒small cell lung cancer (NSCLC) is a heterogeneous disease with multiple treatment options dependent upon staging, presence of metastasis, and patient factors—including presence of comorbidities—among other considerations. As such, current treatment options include surgical resection, chemotherapy, radiation, immunotherapy, and targeted therapy.
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Lung Cancer is the Model for Precision Medicine, Expert Says
November 14th 2017In a presentation at the 35th annual CFS, Edward S. Kim, MD, discussed the "renaissance" in the non–small cell lung cancer landscape that has come with the rapid evolution of targeted treatment for patients with <em>EGFR</em>-mutation–positive disease.
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Serum Tumor Markers Used to Monitor Therapeutic Outcomes in NSCLC
November 13th 2017Four tumor serum markers commonly used in other solid tumors could be used in monitoring therapeutic outcomes in patients with stage IV lung adenocarcinoma, according to a single-center retrospective analysis.
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Comparing Alectinib Versus Crizotinib in ALK+ NSCLC
November 13th 2017David R. Gandara, MD, director, Thoracic Oncology Program, professor, senior advisor to director, UC Davis Comprehensive Cancer Center, UC Davis Health System, discusses results of the ALEX clinical trial, which compared alectinib (Alecensa) versus crizotinib (Xalkori) in patients with ALK+ non–small cell lung cancer (NSCLC).
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Treating Patients With Stage IV Lung Adenocarcinoma Without Actionable Oncogenic Drivers
November 11th 2017H. Jack West, MD, a thoracic oncologist of Swedish Cancer Institute at Swedish Medical Center, discusses appropriate treatment for patients with stage IV adenocarcinoma who do not harbor oncogenic drivers.
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Alectinib Approved by FDA for Frontline Treatment of ALK-Positive NSCLC
November 7th 2017Alectinib (Alecensa) has received FDA approval for the frontline treatment of patients with ALK-positive metastatic non–small cell lung cancer, Genentech, the manufacturer of the second-generation ALK inhibitor, announced today.
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The Significance of Results for Entrectinib in ROS1+ NSCLC
October 24th 2017Robert C. Doebele, MD, PhD, associate professor, Division of Medical Oncology, University of Colorado, discusses the significance of the results of a trial exploring entrectinib in patients with ROS1-positive non–small cell lung cancer (NSCLC).
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Durvalumab Granted FDA's Priority Review for Locally Advanced Unresectable NSCLC
October 17th 2017Based on positive progression-free survival results from the PACIFIC trial, a supplemental biologics license application for durvalumab (Imfinzi) for the treatment of patients with stage III, unresectable non–small cell lung cancer has been granted a priority review by the FDA.
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Abemaciclib Fails to Improve OS in KRAS+ NSCLC
October 12th 2017Abemaciclib (Verzenio) failed to meet its primary endpoint of improving overall survival versus erlotinib (Tarceva) in patients with <em>KRAS</em>-mutated, advanced non–small cell lung cancer who progressed after platinum-based chemotherapy, according to topline results from the phase III JUNIPER trial.
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FDA Grants Osimertinib Breakthrough Therapy Designation for First-Line NSCLC
October 12th 2017Osimertinib (Tagrisso) has been granted Breakthrough Therapy Designation by the FDA for the first-line treatment of patients with metastatic <em>EGFR </em>mutation-positive non-small cell lung cancer (NSCLC).
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Dr. Vokes Discusses PARP Inhibitors in Lung Cancer
October 12th 2017Everett E. Vokes, MD, John E. Ultmann Professor of Medicine and Radiation Oncology, physician-in-chief, University of Chicago Medicine, and biological sciences chair, department of medicine, discusses PARP inhibitors for the treatment of lung cancer.
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More Evidence of Osimertinib's Activity Against Brain Lesions
September 22nd 2017The third-generation EGFR inhibitor osimertinib had substantial clinical activity against brain metastases in Asia-Pacific patients with advanced non–small cell lung cancer harboring the <em>T790M</em> resistance mutation, an updated analysis of a randomized trial showed.
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Dr. West Discusses Results of the Phase III FLAURA Study in NSCLC
September 20th 2017H. Jack West, MD, medical oncologist, Swedish Cancer Institute of Swedish Medical Center, discusses the results of the phase III FLAURA study of frontline osimertinib (Tagrisso) in patients with EGFR-mutant non–small cell lung cancer (NSCLC).
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Study Identifies Subset of NSCLC Patients Who Experience Hyperprogression After Immunotherapy
September 19th 2017A multicenter retrospective analysis presented at the 2017 ESMO Congress found that a newly defined subset of patients treated with anti-PD-1/PD-L1 immunotherapy experienced accelerated tumor growth indicative of hyperprogressive disease (HPD).
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Frontline Dabrafenib/Trametinib Combo Shows Promising Efficacy in BRAF+ NSCLC
September 19th 2017Frontline treatment with the combination of dabrafenib and trametinib induced an objective response rate of 64% (95% CI, 46%-79%) and a disease control rate of 75% in patients with <em>BRAF</em>-mutant metastatic non–small cell lung cancer.
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Vx-001, a cancer vaccine that employs a new strategy targeting a universal tumor antigen, significantly improved overall survival in patients with advanced or metastatic non–small cell lung cancer who developed an immune response to the vaccine, according to findings presented at the 2017 ESMO Annual Congress in Madrid, Spain.
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ABP-215, First Biosimilar for Cancer Treatment, Approved by FDA
September 15th 2017Today, ABP-215, a biosimilar for bevacizumab developed by Amgen and Allergan, received FDA approval for the treatment of several different cancer types, making it the first biosimilar approved for the treatment of cancer.
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Investigational RET Inhibitor RXDX-105 Active in NSCLC
September 14th 2017An investigational RET inhibitor demonstrated clinical activity in a subgroup of patients with RET fusion-positive non–small cell lung cancer (NSCLC), according to data from a phase Ib trial reported at the ESMO Annual Congress in Madrid.<br />
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