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Chronic GvHD MUD HCT for AML Despite Tacrolimus/Methotrexate Prophylaxis

Case Based Peer Perspectives

Safety Concerns with Ruxolitinib

Videos

Dr. Cutler discusses the management of chronic graft-versus-host disease (cGvHD) in a 48-year-old man who developed cGvHD after undergoing a matched unrelated donor (MUD) hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML), despite receiving tacrolimus and methotrexate as prophylaxis.

Exploring the main treatment goals and current first-line and second-line treatment options for patients with chronic GvHD.

Treatment Goals and Options for Chronic GvHD

Discussing the appropriateness of the initial therapy based on the NCCN guidelines for the given patient case.

Appropriateness of Initial Therapy for Chronic GvHD

Examining the efficacy and safety findings from recent studies on ibrutinib, ruxolitinib, and Belumosudil for chronic GvHD, and their implications for treatment choices.

Efficacy and Safety of Emerging Therapies

Discussing the key safety issues observed with ruxolitinib treatment in the REACH-3 trial and evaluating the risk/benefit profile for patients with steroid-refractory chronic GvHD.

Safety Profile of GVHD Treatment Options

Exploring general principles and practices for monitoring and mitigating adverse events in patients with chronic GvHD treated with systemic agents, and determining when dose modification or treatment discontinuation is warranted.

Monitoring and Mitigating Adverse Events

Discussing how various treatments for chronic GvHD impact quality of life in terms of disease response and side effects.

Quality of Life Impact

Evaluating the significance of the AGAVE-201 trial results for axatilimab in refractory chronic GvHD and key factors to consider when assessing the data.

Axatilimab Trial Results

Discussing perspectives on the future landscape of chronic GvHD management, including limitations of current targeted treatment options and emerging research of interest.

Future Landscape of cGvHD Management

Safety Profile of GVHD Treatment Options

EP: 1.Treatment Goals and Options for Chronic GvHD

EP: 2.Appropriateness of Initial Therapy for Chronic GvHD

EP: 3.Efficacy and Safety of Emerging Therapies

EP: 4.Safety Profile of GVHD Treatment Options

EP: 5.Monitoring and Mitigating Adverse Events

EP: 6.Quality of Life Impact

EP: 7.Axatilimab Trial Results

EP: 8.Future Landscape of cGvHD Management