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Opinion|Videos|March 25, 2025

Academic Perspectives on Treatment Decisions for BPDCN

Author(s)Marlise R. Luskin, MD, MSCE

An expert discusses how, for younger/fitter patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), treatment selection as a bridge to transplant is based on efficacy, toxicity, and response depth. Patient-specific (age, comorbidities) and systemic (drug access, center expertise) factors guide decisions. Emerging real-world evidence, such as Berning et al (ASH 2024), highlights CD123-targeted therapy’s role in optimizing response rates before allogeneic stem cell transplantation (allo-SCT).

Episodes in this series

1 expert in this video

EP. 1 A 62-Year-Old Man Who Is Newly Diagnosed With BPDCN

1 expert in this video

EP. 2 Understanding BPDCN: From Disease Presentation to Diagnosis

1 expert in this video

EP. 3 An Overview of Treatment Approaches for BPDCN

1 expert in this video

EP. 4 The Role of CD123 Targeted Therapy (tagraxofusp) in the Evolving Treatment Landscape for BPDCN

1 expert in this video

EP. 5 Academic Perspectives on Treatment Decisions for BPDCN

1 expert in this video

EP. 6 Adverse Events Monitoring and Management in BPDCN Treatment

1 expert in this video

EP. 7 Treatment Implementation and Long-Term Considerations in BPDCN

Video content above is prompted by the following:

For patients with BPDCN who are younger/fitter, how do you determine which treatment options provide the greatest benefit as a bridge to transplant?
What patient-specific and systemic/logistical factors influence your treatment choice?
What are your thoughts on real-world evidence that evaluates response rates with CD123/consolidative allo-SCT in BPDCN (Berning et al, ASH 2024)?

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