Patient Profile: A 73-Year-Old Man with EGFR+ NSCLC

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EP: 1.Patient Profile: A 73-Year-Old Man with EGFR+ NSCLC

EP: 2.Overview of Treatment Options for EGFR+ NSCLC

EP: 3.EGFR+ NSCLC: Recent Data From FLAURA2

EP: 4.Updates from MARIPOSA Trial in EGFR+ NSCLC

EP: 5.Treatment Decision-Making for Patients With EGFR+ NSCLC

EP: 6.PAPILLON: Amivantamab Plus Chemotherapy in Patients With NSCLC Positive for EGFR Mutations

EP: 7.Key Takeaways on Treating Patients With EGFR+ NSCLC

Case: A 73-Year-Old Man with EGFR+ NSCLC

Clinical Presentation:

• 73-year-old man initially presents with complaints of a persistent nonproductive cough, dyspnea on mild exertion, and an unintentional 10 lb. weight loss over prior 3 months

Past Medical History:

• Coronary Artery Disease: treated with rosuvastatin 20 mg QD.
• Hypertension, controlled on ARB QD.
• Hyperlipidemia, treated with atorvastatin 20 mg QD.
• COPD, maintained on triple inhalation therapy BID.

Social History:

• Retired high school teacher; married with 2 adult children.
• 50 pack-year smoking history: quit tobacco habit 5 years previously

Initial Clinical Workup and Diagnosis:

Physical Examination

• Ambulatory but no longer drives and is capable of self-care without assistance.
• Height: 5’10”; Weight:78 kg (172 lbs.)
• ECOG PS: 1
• Diminished breath sounds auscultated over right upper lobe.

Pulmonary Function Tests

• FEV1 2.1 L (68% predicted) indicative of moderate obstruction.

Imaging Studies:

• Chest CT: showed a 4.2 x 3.1 cm spiculated mass in the right upper lobe with suspected hilar lymph node involvement.
• PET Scan: confirms hypermetabolic right hilar and subcarinal lymph nodes activity suggestive of malignancy.
• MRI of Abdomen and Brain and Tech99 Bone Scintigraphy: no evidence of metastases.

Diagnostic Procedure:

• Bronchoscopy with Biopsy: gross appearance of specimen obtained from right upper lobe consistent with adenocarcinoma of the lung.
  • Histopathology: confirms lung adenocarcinoma (Grade 2; pT2b pN1 [2/17 lymph nodes positive]; V0 R0), with partially papillary and partially tubular morphology.

Neoadjuvant Therapy and Surgical Resection:

• Patient receives 4 cycles of cisplatin + pembrolizumab + pemetrexed.
• He tolerated the regimen well with manageable episodes of fatigue, nausea, and sporadic neuropathy of the bilateral upper extremities.
• Post-Treatment Restaging PET Scan: showed a good partial response.
• Surgical Resection:
  • Lobectomy of the RUL with hilar and mediastinal lymphadenectomy via video-assisted thoracoscopic surgery (VATS).

Surgical Pathology Report:

• ypT2aN1 (3/16 lymph nodes positive) with negative margins; Stage IIa
  • Adjuvant RT was recommended, but the patient declined.

Six Months Later:

• Patient returns to his oncologist with complaints of recurrent, mid-to-low back pain.
• Post-Operative Chest CT: displays scattered pulmonary nodules suspicious for metastatic disease progression.
• Thoraco-lumbar MRI: negative for bony metastases.

Second Line Systemic Therapy:

• Amivantamab was initiated with a weekly, weight-based infusion x4w(split dose, Days 1-2, Week 1), and thereafter q2w.
• The patient developed a minor infusion reaction on day 1 of therapy, which resolved with application of cool compresses to the site and acetaminophen, 500 mg PO q4h, prn.

Repeat Imaging at 8 Weeks:

• The patient experienced a good partial response.
  • He will continue to be followed regularly by his oncologist.

This is a video synopsis/summary of a Case-Based Peer Perspectives featuring Joshua K. Sabari, MD.

This video features a discussion on the case of a 73-year-old man with a 50 pack-year smoking history who presented with a persistent nonproductive cough, dyspnea on exertion, and a 10-pound unintentional weight loss over 3 months. His medical history was significant for coronary artery disease, hypertension, hyperlipidemia, and chronic obstructive pulmonary disease (COPD) treated with inhalers. Imaging revealed a 4.2 x 3.1-cm speculated right upper lobe lung mass and enlarged hilar and subcarinal lymph nodes concerning for malignancy. Biopsy confirmed lung adenocarcinoma.

After neoadjuvant chemotherapy with cisplatin, pembrolizumab, and pemetrexed, plus surgical resection, he was found to have stage IIA lung cancer. Six months later he developed scattered pulmonary nodules suspicious for metastatic disease. Biopsy confirmed recurrent metastatic lung adenocarcinoma, and molecular testing identified an exon 21 L858R EGFR mutation.

He was started on osimertinib 80 mg orally daily and had an initial response. He will continue routine follow-up with his oncologist for recurrent metastatic EGFR-mutant non–small cell lung cancer.

Video synopsis is AI-generated and reviewed by Targeted Oncology™ editorial staff.