Uma Borate, MBBS, and the Oncology Brothers provide insights gleaned from the MANIFEST-2 study, a phase 3, randomized, double-blind study on pelabresib plus ruxolitinib for JAK inhibitor treatment–naïve patients with myelofibrosis.
Ruxolitinib Shows Promise in Preventing GVHD in Myelofibrosis
A phase 2 study evaluated the use of ruxolitinib plus standard GVHD prophylaxis in patients with myelofibrosis undergoing transplant.
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Consistent Response, Durability Shown by Axatilimab Regardless of Prior Lines of Therapy in cGVHD
Axatilimab demonstrated consistent response and durability in chronic graft-versus-host disease, regardless of prior treatments, in a phase 1 AGAVE-201 trial analysis.
FDA Approves Brentuximab Vedotin Triplet in R/R Large B-cell Lymphoma
The FDA approved brentuximab vedotin, lenalidomide, and rituximab for large B-cell lymphoma after 2 therapies in patients ineligible for transplant or chimeric antigen receptor T-cell therapy.
The Clinical Impact of Biased Language in Handoffs
Negative language about patients can reduce clinician empathy and recall of critical health details, a recent study finds.
Highlights of ASH: Lymphoid Malignancies
ASH 2024 featured practice-changing studies in lymphoid malignancies, including tafasitamab’s impact in FL, ibrutinib’s OS benefit in MCL, and promising epcoritamab data in CLL.
Phase 3 waveLINE-010 Study Starts for Zilovertamab Vedotin in DLBCL
The phase 3 waveLINE-010 trial is evaluating zilovertamab vedotin plus R-CHP vs R-CHOP for the treatment of untreated diffuse large B-cell lymphoma.