Emerging JAK Inhibitors for Patients With Myelofibrosis

Opinion
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Dr Oh discusses emerging JAK inhibitors in the myelofibrosis treatment landscape, highlighting clinical evidence that supports their use.

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    Case: A 63-Year-Old Man with Myelofibrosis

    Clinical Presentation:

    • A 63-year-old man recently diagnosed with primary MF and initiated on 10 mg BID ruxolitinib.
    • PMH: type 2 diabetes, hypercholesteremia, and hypertension, squamous cell carcinoma (SCC)

    Follow up and Clinical Workup at 3 Months:

    • Exam: night sweats improved.
    • Labs: Hb 7.8 g/dL; Plt 80 x 109/L (previously 135k) stabilized.
    • Some spleen reduction.
    • Patient receives ~1 unit RBC per month.

    Follow up and Clinical Workup at 6 Months:

    • Patient reports complaints of fatigue and abdominal pain.
    • Labs: Plt 55 x 109/L; Hgb 6.8 g/dL
    • Patient now receives 2 units RBC per month.
    • Experienced recurrence of SCC.

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