T Cell Resistance to TGF-Beta in Lymphoma
Catherine Bollard, MBChB, MD, from the Baylor College of Medicine, discusses T cells and TGF-beta in Hodgkin's lymphoma and Non-Hodgkin lymphoma.
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The Wnt Pathway and its Role in Colorectal Cancer
S. Gail Eckhardt, MD, Professor and Head of the Division of Medical Oncology at the University of Colorado Denver and Health Sciences Center, discusses the wnt pathway and its role in colorectal cancer.
Gene Assays and the Treatment of Breast Cancer
Kathy S. Albain, MD, from Loyola University Chicago, discusses gene assays as they relate to the treatment of patients with breast cancer.
PROFILE 1007 Trial: Crizotinib vs Pemetrexed or Docetaxel in NSCLC
D. Ross Camidge, MD, PhD, comments on the subgroup analysis of the PROFILE 1007 trial, which looked at crizotinib versus either pemetrexed or docetaxel in NSCLC.
Improving Lung Cancer Drug Development
Tony S.K. Mok, BMSc, MD, FRCPC, from the Prince of Wales Hospital Hong Kong, China, discusses how to improve the strategy of developing treatments for lung cancer.
Afatinib for Patients With EGFR Mutation
Paul A. Bunn, Jr, MD, from the University of Colorado, discusses afatinib for patients with activating epidermal growth factor receptor mutation.
PROSTVAC in Castration-Resistant Prostate Cancer
James L. Gulley, MD, PhD, discusses how PROSTVAC works in patients with castration-resistant prostate cancer.
Clincal Trial Endpoints in Ovarian Cancer
Carol Aghajanian, MD, from the Memorial Sloan-Kettering Cancer Center, discusses the difficulties with a gold standard clinical trial endpoint in ovarian cancer.
Advances in the Treatment of Lung Cancer
David P. Carbone, MD, PhD, from the The Ohio State University Wexner Medical Center, discusses advances in the treatment of lung cancer.
MEK Inhibitors for the Treatment of Melanoma
Alex A. Adjei, MD, PhD, discusses the use of MEK inhibitors when treating patients with melanoma.
The E75 Vaccine for Breast Cancer
Elizabeth Mittendorf, MD, PhD, from the University of Texas MD Anderson Cancer Center, gives an overview of how the E75 vaccine works in breast cancer.
BTK Inhibition and the Mechanism of Action of Ibrutinib
Jennifer Woyach, MD, discusses Bruton's tyrosine kinase inhibition and the mechanism of action of ibrutinib.
Therapeutic Index of Targeted Therapies and Conventional Cytotoxics
Grace Dy, MD, from the Roswell Park Cancer Institute, discusses the therapeutic index of targeted therapies and conventional cytotoxics.
Drug Sequencing in Melanoma
Jeffrey A. Sosman, MD, from the Vanderbilt-Ingram Cancer Center, discusses drug sequencing for patients with melanoma at the 11th Annual International Congress on Targeted Therapies in Cancer.
CAR-Modified T Cells for the Treatment of Solid Tumors
Renier J. Brentjens, MD, PhD, from Memorial Sloan-Kettering Cancer Center, discusses the potential efficacy of CAR-modified T cells for the treatment of solid tumors.
The Efficacy of Immune Checkpoint Inhibitors
Roy S. Herbst, MD, PhD, from the Yale Cancer Center, describes immunotherapy as one of the most exciting advances in cancer care.
The Potential of HSP Inhibitors as Radiation Sensitizers
Laurie Gaspar, MD, from the University of Colorado School of Medicine, discusses the potential of heat shock protein (HSP) inhibitors as radiation sensitizers.
An Overview of the Treatment of Hematologic Malignancies
Julian Adams, PhD, from Infinity Pharmaceuticals, discusses PI3K inhibitors and chemotherapies for the treatment of hematologic malignancies.
CELLSEARCH Circulating Tumor Cell Test
Minetta Liu, MD, Breast Cancer Specialist, Mayo Clinic, Rochester, Minnesota, describes the CELLSEARCH® CTC Test, which allows for an assessment of patient prognosis.
The Impact of Sequestration
Richard L. Schilsky, MD, from the University of Chicago Comprehensive Cancer Center, discusses the impact that sequestration had on the FDA.
The Investigation of Immunotherapy in Lung Cancer
David P. Carbone, MD, PhD, from the Ohio State University Comprehensive Cancer Center, discusses the exploration of immunotherapies as treatments for patients with advanced lung cancer.
LDK378 in ALK+ Crizotinib-Resistant NSCLC Patients
Alice T. Shaw, MD, PhD, discusses the results of a trial looking at LDK378 for patients with ALK+ crizotinib-resistant non-small cell lung cancer.
Treating Breast Cancer With Anthracyclines and Trastuzumab
Debu Tripathy, MD, from the Norris Comprehensive Cancer Center, discusses the treatment of breast cancer with anthracyclines and trastuzumab.
Patient Considerations Following Treatment With Radium-223
Neal D. Shore, MD, FACS, discusses patient considerations following treatment with radium-223 for bone metastases from prostate cancer.
Targeting the MAGE-A3 Protein in Lung Cancer
Silvia Novello, MD, PhD, from the University of Turin, Italy, gives an overview of immunotherapy and the targeting of the MAGE-A3 protein in lung cancer.
Cervical Cancer Screening in Low-Resource Countries
Electra D. Paskett, PhD, Professor, College of Medicine, The Ohio State University, discusses screening for cervical cancer.
Trials Show How Nivolumab works in Melanoma
Lynn M. Schuchter, MD, describes two trials presented at the 2013 ASCO Meeting looking at nivolumab in patients with melanoma.
Targeting the Androgen Receptor in Breast Cancer
Suzanne A. W. Fuqua, PhD, professor of medicine at Baylor College of Medicine, discusses targeting the androgen receptor in breast cancer.
The Mechanism of Action of Olaparib
Jane Robertson, MD, Global Product Vice President at AstraZeneca, describes the mechanism of action of the PARP inhibitor olaparib.
How T-rapa Cells Work
Daniel H. Fowler, MD, senior investigator, Center for Cancer Research, National Cancer Institute, describes how T-rapa cells work.