Clincal Trial Endpoints in Ovarian Cancer
Carol Aghajanian, MD, from the Memorial Sloan-Kettering Cancer Center, discusses the difficulties with a gold standard clinical trial endpoint in ovarian cancer.
Carol Aghajanian, MD, from the Memorial Sloan-Kettering Cancer Center, discusses the difficulties with a gold standard clinical trial endpoint in ovarian cancer.
The oncology community would like to see a gold standard of improved overall survival or at least a good way to measure clinical benefit, Aghajanian says. Patients with ovarian cancer live for a long time, receive multiple lines of therapy, and often cross over, in a sense, to receive therapies in the same class.
These factors make it difficult to measure overall survival.
Clinical Pearls
- The oncology community is still developing a good way to measure clinical benefit in ovarian cancer
- Creating a gold standard endpoint for ovarian cancer is difficult due to patient parameters
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