Ponatinib Plus Blinatumomab Shows Potential as a Chemo-Free Option for Ph+ ALL
June 4th 2021Early results of a phase 2 study show that the efficacy achieved with the combination of ponatinib and blinatumomab represents a potentially promising chemotherapy-free, hematopoietic stem cell transplant–sparing treatment for patients with Philadelphia chromosome–positive acute lymphocytic leukemia.
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Increased Responses to Lifileucel Plus Pembrolizumab Observed in Patients With Advanced Melanoma
June 4th 2021In patients with pre-immune checkpoint inhibitor-naïve advanced melanoma, treatment with the combination of lifileucel plus pembrolizumab, compared to pembrolizumab alone, increased the overall response rate.
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Long-Term Survival Benefit with Durvalumab in NSCLC Confirmed in Updated Findings
June 4th 2021Sustained overall survival and progression-free survival benefits was confirmed following long-term treatment with durvalumab following chemoradation in patients with unresectable stage 3 non-small cell lung cancer whose disease had not progressed after platinum-based concurrent chemoradiotherapy.
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Frontline Nivolumab Plus Ipilimumab Show Long-Term Benefit in mNSCLC
June 4th 2021After 4 years of treatment with the combination of nivolumab and ipilimumab, the therapy showed durable, long-term overall survival benefit compared with chemotherapy in patients with advanced non‒small cell lung cancer regardless of PD-L1 expression or histology.
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Mobocertinib Induces Anticancer Responses in Platinum-Pretreated EGFR 20 Insertion+ Advanced NSCLC
June 4th 2021Mobocertinib, elicited rapid, deep, and durable responses and demonstrated a tolerable safety profile in patients with platinum-pretreated EGFR exon 20 insertion–positive metastatic non–small cell lung cancer in a phase 1/2 study.
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Tucatinib Concentrations Measured in CSF of Patients With HER2+ Metastatic Breast Cancer
June 4th 2021In a pharmacokinetic analysis of the first 15 patients in the phase 2 TBCRC049 study, researchers saw the first evidence for concentrations of tucatinib and ONT-993 in the cerebral spinal fluid of patients with HER2+ metastatic breast cancer with newly diagnosed leptomeningeal metastasis.
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Investigational PSMA-Targeted Treatment Demonstrates Antitumor Activity in mCRPC
June 4th 2021In patients with metastatic castration-resistant prostate cancer treated in a phase 1/2a study, the HPN424, a tri-specific half-life extended prostate-specific membrane antigen-targeting T cell engager was well tolerated and demonstrated antitumor activity.
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Cilta-Cel Elicits Deep Response Early On in Patients With R/R Multiple Myeloma
June 4th 2021One infusion of ciltacabtagene autoleucel lead to early and deep responses in a cohort of patients previously treated for relapsed/refractory multiple myeloma, according to findings the phase 2 CARTITUDE-2 study.
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Pralsentinib Demonstrates Tolerability and Elicits Durable Responses in RET Fusion-Positive NSCLC
June 4th 2021In the phase 1/2 ARROW study, pralsentinib was found to be well-tolerated and showed durable responses as treatment of patients with RET fusion-positive non-small cell lung cancer, including those who were not eligible for platinum-based therapy.
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In Some Heavily Pretreated Patients with R/R MM Ide-Cel Continues to Show Deep and Durable Responses
June 4th 2021Long-term follow-up data from the KarMMa trial found that treatment with the chimeric antigen receptor T-cell therapy, idecabtagene vicleucel, continues to demonstrate improved survival among heavily pretreated patients with relapsed/refractory multiple myeloma.
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Increased Dose of Ripretinib Improves Survival in Heavily Pretreated Advanced GIST
June 4th 2021Patients with advanced gastrointestinal stromal tumor after receiving fourth-line therapy had extended progression-free survival when given an intra-patient dose escalation of ripretinib to 150 mg twice a day following progression.
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Niraparib Maintenance Prolongs PFS in BRCA-Positive Ovarian Cancer
June 4th 2021In patients with ovarian cancer and BRCA mutations who were enrolled in 3 different trials, maintenance treatment with niraparib improved progression-free survival compared with placebo with no new safety signals.
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Adjuvant Chemotherapy Does Not Improve 5-Year Overall Survival in Locally Advanced Cervical Cancer
June 3rd 2021In women with locally advanced cervical cancer, administering adjuvant chemotherapy following standard cisplatin-based chemoradiation did not improve survival outcomes, according to findings from the phase 3 OUTBACK trial.
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Adjuvant Pembrolizumab Significantly Reduces Risk of Disease Recurrence or Death in RCC
June 3rd 2021Data from the phase 3 KEYNOTE-564 trial presented in a press briefing ahead of the 2021 ASCO Annual Meeting showed that adjuvant pembrolizuumab achieved significant disease-free survival improvement compared with placebo.
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Lower Medicaid Eligibility May Equate to Worse Cancer Survival Rates
May 19th 2021Policies may be needed to expand Medicaid access to patients, after investigators found worse long-term survival outcomes for patients who lived in states with lower income eligibility rather than higher income eligibility.
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Breast Cancer Testing May Benefit from the Multi-Omics Approach Over Biomarker Assessment Alone
April 13th 2021For patients with metastatic breast cancer, research suggests that utilizing a multi-omics approach to personalized therapy that incorporates information about actionable oncogenic drivers with critical biological data may be feasible and better than DNA sequencing alone.
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Telisotuzumab Vedotin Shows Promising Efficacy and Safety Results for c-Met+ NSCLC
April 13th 2021Telisotuzumab vedotin monotherapy demonstrated a promising objective response rate and has a tolerable safety profile in patients with previously treated c-Met–positive advanced non–small cell lung cancer, according to findings from a phase 2 trial presented in a poster at the American Association for Cancer Research Annual Meeting 2021.
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