Neoadjuvant Anthracycline-Free Regimen Achieves pCR With Less Toxicity in HER2+ Breast Cancer
June 6th 2021Pertuzumab, trastuzumab, and nab-paclitaxel used as neoadjuvant therapy in patients with HER2-positive locally advanced breast cancer showed comparable pathologic complete response with docetaxel, carboplatin, trastuzumab, and pertuzumab with less toxicities.
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The Safety Profile of Amivantamab and Lazertinib in EGFR-Mutant NSCLC
June 6th 2021Alexander Spira, MD, PhD, FACP, director of the Virginia Cancer Specialists Research Institute, discusses the safety profile of amivantamab and lazertinib in EGFR-mutated non-small cell lung cancer, based on data from the CHRYSALIS tria.
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In patients with advanced or metastatic esophageal squamous cell carcinoma, Camrelizumab in combination with chemotherapy demonstrated improved overall survival and progression-free survival and a manageable safety profile as frontline therapy compared with placebo plus chemotherapy.
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Overall survival in postmenopausal patients with hormone receptor–positive, HER2-negative advanced breast cancer at almost 5 years of follow-up continued to improve with Ribociclib plus fulvestrant over fulvestrant alone, irrespective of whether patients received the regimen in the first- or second-line setting.
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ARROW Update Shows Pralsetinib Has Durable Anti-Tumor Activity in RET+ Solid Tumors
June 5th 2021In an update of the ARROW trial, pralsetinib was well tolerated and demonstrated robust and durable anti-tumor activity in heavily pretreated patients with multiple RET fusion–positive advanced solid tumors.
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Niraparib Safe and Well Tolerated in Platinum-Sensitive Recurrent Ovarian Cancer
June 5th 2021Niraparib has an acceptable safety profile for patients with platinum-sensitive recurrent ovarian cancer, regardless of the dose being adjusted for weight, according to updated results from the phase 3 NORMA trial.
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Frontline Ibrutinib Sustains OS Benefit in Chronic Lymphocytic Leukemia
June 5th 2021Based on 7-year follow-up data, the use of front-line ibrutinib monotherapy has sustained progression-free survival and overall survival benefit compared with chlorambucil as treatment of patients with chronic lymphocytic leukemia.
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Long-Term Clinical Benefit Potential Seen with KTE-X19 for Relapsed/Refractory B-ALL
June 4th 2021A robust and durable response was seen in heavily pretreated patients with relapsed/refractory B-cell acute lymphoblastic leukemia after receiving a single infusion of KTE-X19, a CAR T-cell therapy.
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Ponatinib Plus Blinatumomab Shows Potential as a Chemo-Free Option for Ph+ ALL
June 4th 2021Early results of a phase 2 study show that the efficacy achieved with the combination of ponatinib and blinatumomab represents a potentially promising chemotherapy-free, hematopoietic stem cell transplant–sparing treatment for patients with Philadelphia chromosome–positive acute lymphocytic leukemia.
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Increased Responses to Lifileucel Plus Pembrolizumab Observed in Patients With Advanced Melanoma
June 4th 2021In patients with pre-immune checkpoint inhibitor-naïve advanced melanoma, treatment with the combination of lifileucel plus pembrolizumab, compared to pembrolizumab alone, increased the overall response rate.
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