FLAG-IDA and Venetoclax Produce Durable Remissions in Newly Diagnosed AML
September 9th 2021The combination of fludarabine, cytarabine, idarubicin and G-CSF and venetoclax produces durable responses and has an acceptable safety profile in patients with newly diagnosed acute myeloid leukemia.
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Tiragolumab-Atezolizumab Combo Shows Preliminary Clinical Activity in Metastatic Esophageal Cancer
July 3rd 2021The combination regimen was well tolerated with promising preliminary anti-tumor activity in patients with heavily pretreated esophageal cancer, who had not received immunotherapy.
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Paclitaxel and GSK2636771 Combo Shows Benefit in Certain Patients with Gastric Cancer
July 2nd 2021The combination of paclitaxel and GSK2636771 showed encouraging antitumor activity and a manageable toxicity profile and in patients with PTEN-deficient advanced gastric cancer who progressed after first line chemotherapy.
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Pooled Data Suggest Obese Patients With CRC May Benefit From Weight-Based Chemotherapy Doses
July 2nd 2021Findings from the OCTOPUS Consortium of trial data have indicated that obese patients with colorectal cancer have a poorer survival from adjuvant chemotherapy treatment due to reduced treatment dose and average cumulative relative dose.
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New Early-Onset Colon Cancer Data Reinforce Need to Reduce Unnecessary Antibiotic Use
July 2nd 2021In a first-of-its-kind study, data reveal that unnecessary antibiotic use may increase the risk of colon cancer—especially in people under age 50. Findings were presented at the 2021 World Congress on Gastrointestinal Cancer.
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Avapritinib Shows Promise in Chinese Patient Population With PDGFRA D842V-Mutant GIST
July 1st 2021Treatment with avapritinib in Chinese patients with PDGFRA D842V-mutant gastrointestinal stromal tumors revealed promising clinical benefit, according to a bridging study of the NAVIGATOR trial.
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Pembrolizumab monotherapy demonstrated improvement in health-related quality of life in patients with previously treated metastatic microsatellite instability-high/ mismatch repair deficient advanced noncolorectal solid tumors, with the biggest improvements seen in those who achieved a complete remission or partial remission.
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Dostarlimab achieved durable antitumor responses in patients with non-endometrial mismatch repair–deficient solid tumors treated in an expansion cohort of the phase 1 GARNET trial, according to interim findings presented during the ESMO World Congress on Gastrointestinal Cancer.
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Treatment with nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with resected pancreatic cancer showed positive 5-year overall survival outcomes that were consistent with the primary analysis of the phase 3 APACT clinical trial as well as a post hoc analysis.
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Lenvatinib Shown to Be Superior to Sorafenib in Frontline HCC in Real-World Study
June 30th 2021A propensity score matching analysis presented in a poster during the 2021 World Congress on Gastrointestinal Cancer demonstrated that lenvatinib was superior to sorafenib as a first-line treatment for patients with unresectable hepatocellular carcinoma.
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Prolonged Reponses Following ASCT and Standard Consolidation/Induction With Daratumumab Maintenance
June 20th 2021Benefit was seen with daratumumab maintenance therapy for patients with newly diagnosed multiple myeloma who received autologous stem cell transplant plus induction and consolidation therapy with bortezomib, thalidomide, and dexamethasone.
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Promising Responses Seen With Intensified Daratumumab Induction in Ultra High–Risk Multiple Myeloma
June 19th 2021Intensified induction therapy with daratumumab plus cyclophosphamide, bortezomib, lenalidomide, and dexamethasone followed by bortezomib-augmented autologous stem cell transplant resulting in deep remissions or patients with ultra¬ high-risk multiple myeloma or primary plasma cell leukemia.
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