Nivolumab Combinations Improve Survival But Are Not Cost-Prohibitive in Advanced ESCC
May 9th 2023An analysis of data from the CheckMate-648 trial sows that while adding nivolumab to either ipilimumab or chemotherapy for patients with advanced esophageal squamous cell carcinoma improves survival outcomes, their current price is not cost-effective for first-line treatment.
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Dual Checkpoint Blockade With Neoadjuvant Chemo Shows Benefit in Ovarian Cancer
March 27th 2023The phase 2 KGOG3046 is the first study to show survival outcomes with the dual checkpoint blockades, durvalumab and tremelimumab, combined with neoadjuvant chemotherapy for the treatment of patients with newly diagnosed advanced ovarian cancer.
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HRQOL Not Affected by Cytoreductive Surgery Plus HIPEC in Ovarian Cancer
March 26th 2023According to Vadim Gushchin, MD, treatment with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy should not be limited by concerns of how it may impact a patient’s health-related quality of life.
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Real-World Data Supports Avelumab Use for Locally Advanced, Metastatic Urothelial Carcinoma
February 20th 2023Treatment with avelumab for locally advanced or metastatic urothelial carcinoma showed to be consistent in a real-world with what was previously seen in the phase 3 JAVELIN Bladder 100 trial.
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Vedolizumab and Standard Prophylaxis Proves Effective in Preventing GI aGVHD
February 19th 2023The phase 3 GRAPHITE study showed that vedolizumab plus standard prophylaxis after unrelated allogeneic hematopoietic stem cell transplantation was more effective vs placebo for the prevention of lower gastrointestinal graft-vs-host disease.
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Iomab-B Shows Significant Improvement in R/R AML Over Chemotherapy Prior to Allogeneic HCT
February 19th 2023In findings from the phase 3 SIERRA trial, Iomab-B-based conditioning for patients with relapsed or refractory acute myeloid leukemia provided significant efficacy and tolerable safety results over the current standard of care.
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Ide-Cel Induces PFS Benefit in Triple-Class-Exposed R/R Multiple Myeloma
February 19th 2023A second interim analysis of the phase 3 Karmma-3 trial demonstrated significantly improved progression-free survival and overall response rates, compared with standard regimens, in patients with triple-class-exposed relapsed/refractory multiple myeloma.
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Cabozantinib and Immunotherapy Combination Improves Efficacy in Advanced Renal Cell Cancer Subgroups
February 18th 2023Cabozantinib improved outcomes over placebo for patients with advanced, intermediate-risk renal cell cancer, and showed some efficacy among poor-risk patients in combination with nivolumab and ipilimumab.
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Cabozantinib Therapy Shows Early Efficacy in Advanced RCC After Checkpoint Inhibitor Combonation
February 18th 2023Early data from the phase 2 CaboPoint trial shows a promising response rate among patients with advanced renal cell carcinoma that progressed after checkpoint inhibitor based combination therapy.
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Long-Term Survival Benefit in Muscle-Invasive Urothelial Cancer Impacted by Nivolumab
February 18th 2023Extended follow-up findings of the phase 3 CheckMate 274 study further support the use of nivolumab as a standard of care in high-risk muscle-invasive urothelial carcinoma following radical resection.
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Antitumor Activity Associated With Pembrolizumab in BCG-Unresponsive Papillary NMIBC
February 18th 2023Pembrolizumab generated antitumor activity in patients with BCG-unresponsive, papillary high-risk non–muscle-invasive bladder cancer, according to cohort B of the phase 2 Keynote-057 trial.
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Chronic Opioid Use After ASCT May Worsen OS in Multiple Myeloma
February 18th 2023A single-center, retrospective study demonstrated high rates of chronic opioid use after autologous stem cell transplantation in patients with multiple myeloma, also leading to inferior overall survival at 6 months of follow-up.
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