November 19th 2024
The FDA has approved FoundationOne Liquid CDx as a companion diagnostic for patients with metastatic non–small cell lung cancer with MET exon 14 skipping alterations eligible for tepotinib.
42nd Annual CFS: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Annual Hawaii Cancer Conference
January 25-26, 2025
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
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Differentiating Adverse Events for Antibody-Drug Conjugates Across Solid Tumor Management
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Efficiency in Cancer Costs Can be Achieved Without Sacrificing Quality, HICOR Report Finds
June 21st 2018The Hutchinson Institute for Cancer Outcomes Research released the first Community Care Cancer in Washington State: Quality and Cost Report to provide transparency for patients and health providers, establishing a more value-based care model.
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Osimertinib Granted European Approval for Frontline Treatment of EGFR-mutant NSCLC
June 12th 2018Osimertinib (Tagrisso) has been approved by The European Commission as a frontline treatment for patients with <em>EGFR</em>-mutant locally-advanced or metastatic non–small cell lung cancer. The approval is based on data from the phase III FLAURA trial.
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Refinements in the Use of Genomic Rearrangements Signals Exciting Times Ahead
June 11th 2018Robert L. Ferris, MD, PhD, Physician Editor-In-Chief of the Journal of Targeted Therapies, discusses genomic rearrangements and the allelic fraction of that genomic rearrangement as a major component of an individual’s cancer.
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Oncology Experts Reflect on Key Takeaways from Data Presented at ASCO Annual Meeting
June 7th 2018The 2018 ASCO Annual Meeting was a great success, with over 40,000 people in attendance and over 5000 abstracts presented from June 1-5 in Chicago, Illinois. Data from several phase III trials in lung cancer were presented, with especially significant results in non–small cell lung cancer. Other big areas during this year’s meeting included breast, gastrointestinal, genitourinary, and hematologic cancers.
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PFS Extended With Addition of Bevacizumab to Erlotinib in EGFR-Mutated NSCLC
June 6th 2018Upfront treatment with the combination of bevacizumab (Avastin) and erlotinib (Tarceva) is superior to erlotinib alone as for patients with non–small cell lung cancer harboring<em> EGFR</em> mutations, according to results of a preplanned interim analysis of the phase III study known as NEJ026.
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Impact of Durvalumab as Consolidation Therapy in NSCLC
June 6th 2018Julie R. Brahmer, MD, associate professor of oncology and co-director of the Upper Aerodigestive Department at the Bloomberg Kimmel Institute for Cancer Immunotherapy, John Hopkins Medicine, discusses the change in standard of care for patients with stage III non–small cell lung cancer. Durvalumab was recently approved by the FDA as a consolidation therapy for patients with stage III locally-advanced, unresectable NSCLC who had not progressed following standard chemoradiotherapy.
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Overall Survival Increased in NSCLC With First-Line Atezolizumab Combination
June 5th 2018Overall survival improved with the combination of atezolizumab, bevacizumab, carboplatin, and paclitaxel versus a treatment regimen of bevacizumab and chemotherapy alone in patients with advanced wild-type nonsquamous non–small cell lung cancer.
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Potential Benefit Found With Pegilodecakin/PD-1 Inhibitor Combo in NSCLC
June 4th 2018According to findings of an early study presented at the 2018 ASCO Annual Meeting, the combination of pegilodecakin and a PD-1 inhibitor demonstrated an overall response rate of 41% in patients with advanced non–small cell lung cancer.
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Risk of Death Reduced With Upfront Pembrolizumab/Chemotherapy in Squamous NSCLC
June 4th 2018According to the phase III KEYNOTE-407 trial, when pembrolizumab was added to frontline carboplatin/paclitaxel or nab-paclitaxel, the combination reduced the risk of death by 36% compared with chemotherapy alone for patients with metastatic squamous non–small cell lung cancer. These results were presented at the 2018 ASCO Annual Meeting.
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KEYNOTE-042 Data Suggest Survival Improvement With Pembrolizumab in NSCLC
June 3rd 2018According to findings from the phase III KEYNOTE-042 trial, patients with non–small cell lung cancer demonstrated improved survival of 4 to 8 extra months with upfront pembrolizumab therapy compared with chemotherapy, the current standard of care. Patients treated with pembrolizumab also experienced fewer adverse events.
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IMPACT Study Shows Benefit of Matched Targeted Therapies for Hard-to-Treat Cancers
June 3rd 2018According to findings of the IMPACT study discussed at the 2018 ASCO Annual Meeting, overall survival was improved with personalized therapy based on tumor molecular profiling in patients with advanced, hard-to-treat cancers.
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Durvalumab Shows Promise in Patients With NSCLC, Brahmer Says
May 31st 2018Julie Brahmer, MD, recently shared the treatment considerations and decisions she makes when treating patients with non–small cell lung cancer (NSCLC). Brahmer, co-director of the Upper Aerodigestive Department, Johns Hopkins Hospital, in Baltimore, Maryland, discussed her treatment considerations based on case scenarios during a <em>Targeted Oncology </em>live case-based peer perspectives presentation.
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Assessing Recent Progress Toward Cancer Cures at Perlmutter Cancer Center
May 30th 2018Benjamin G. Neel, MD, PhD, director of the Laura and Isaac Perlmutter Cancer Center at NYU Langone, discusses how his institution has changed vastly over the last few years, with an increasing number of clinical trials available for patients with lung cancer and other cancers. Clinical trials are often the best option for cancers where the outcomes with conventional treatments may be uncertain, Neel says.
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Crizotinib Granted Breakthrough Designation by FDA for MET+ NSCLC and ALK+ ALCL
May 30th 2018Crizotinib has been granted a breakthrough therapy designation by the FDA for the treatment of patients with metastatic non–small cell lung cancer with MET exon 14 alterations who progress after receiving platinum-based chemotherapy. Additionally, the kinase inhibitor was granted a designation for use patients with relapsed/refractory ALK+ anaplastic large cell lymphoma.
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Two Studies Investigating Daratumumab/Checkpoint Inhibitor Combos in NSCLC, Myeloma Terminated
May 30th 2018Following a planned interim analysis, 2 early-phase clinical trials exploring daratumumab in combination with either a PD-1 inhibitor for multiple myeloma or a PD-L1 inhibitor for non–small cell lung cancer have been terminated, according to a statement from Genmab, the company codeveloping daratumumab with Janssen.
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