Misako Nagasaka, MD, PhD discusses a patient case involving a 47-Year-Old Woman with EGFR-mutated Advanced/Metastatic NSCLC and discusses optimizing 1L EGFR-mutant NSCLC care requires balancing efficacy and toxicity in combination therapies. She also reviews MARIPOSA/FLAURA2 data inform sequencing, AE management, resistance testing, and future innovations.