Lori J. Wirth, MD, is the medical director of the Center for Head and Neck Cancers at Massachusetts General Hospital.
Investigational Agents and Ongoing Clinical Trials in Advanced RAI-R-DTC
Dr Lori Wirth highlights exciting clinical trials in advanced RAI-R-DTC and investigational agents to look out for in the future.
An Overview of Advanced Radioactive Iodine-Refractory Differentiated Thyroid Cancer (RAI-R-DTC)
Lori Wirth, MD, provides a brief overview of advanced radioactive iodine-refractory differentiated thyroid cancer, or RAI-R-DTC.
Novel Approach to Next-Generation Sequencing of NTRK Tumors
Lori J. Wirth, MD, discusses a new assay with the ability to perform DNA and RNA sequencing to better detect gene fusions.
NTRK Inhibitor Treatment for Patients With Thyroid Cancers
Lori J. Wirth, MD, explains the role of NTRK inhibitor in TRK fusion-positive thyroid cancer treatment.
Sequencing Therapies for Advanced Thyroid Cancer After an NTRK Inhibitor
Lori J. Wirth, MD, discusses sequencing therapies for patients with NTRK fusion–positive advanced thyroid cancer.
Selecting Treatment for NTRK-Positive Iodine-Refractory Thyroid Cancer
Lori J. Wirth, MD, discusses the treatment options now available for patients with iodine-refractory differentiated thyroid cancer.
Using Targeted Therapies for NTRK-Fusion-Positive Thyroid Cancer
Lori Wirth, MD, discusses her experience with NTRK-targeted therapies for patients with thyroid cancer.
Larotrectinib Shows High Efficacy in Differentiated Thyroid Cancer
Lori Wirth, MD, discusses the subanalysis of patients with thyroid cancer with NTRK fusion mutations in clinical trials for larotrectinib.
Future Considerations in the Management of Differentiated Thyroid Cancer
Lori Wirth, MD, discusses unmet needs and future considerations in the management of differentiated thyroid cancer.
Post Hoc Analysis of Patients With Lung Metastases from the SELECT Trial
Lori Wirth, MD, reviews key efficacy data from the post hoc analysis of the SELECT trial investigating the use of lenvatinib in patients with lung metastases.
Clinical Practice Implications From the SELECT Trial
An overview of how SELECT trial data affected clinical treatment practice for patients with differentiated thyroid cancer.
Treatment Options for Patients With Radioiodine-Refractory Metastatic Disease
Medical oncologist Lori Wirth, MD, discusses treatment options for patients with radioiodine-refractory metastatic disease.
Treatment Options for Patients With Differentiated Thyroid Cancer
Lori Wirth, MD, discusses treatment options and potential adverse effects for differentiated thyroid cancer.
Overview and Diagnosis of Differentiated Thyroid Cancer
Lori Wirth, MD, provides an overview and diagnosis consideration of differentiated thyroid cancer and its related subtypes.
DTC Management: Advice and the Future of Treatment
TKI Therapy: Impact of Age and Adverse Events
Differentiated Thyroid Cancer: Initial Management
A 64-Year-Old Man With Differentiated Thyroid Cancer
A discussion on the management of a 64-year-old man with differentiated thyroid cancer, with special consider of the phase 3 SELECT trial regimen.
Recommendations for Treatment of RR-DTC
RR-DTC: Phase 3 SELECT Trial
NCCN Guidelines for First-Line Treatment of RR-DTC
Defining Radioiodine-Refractory DTC
Initial Management of RR-DTC
67-Year-Old Woman With Differentiated Thyroid Cancer
A 67-Year-Old Woman With Differentiated Thyroid Cancer
Lori Wirth, MD, provides insight on the case of a 67-year-old woman with differentiated thyroid cancer and examines the management of radioiodine-refractory disease.
Frequency of RET Alterations in Thyroid Cancers
Lori J. Wirth, MD, associate professor of medicine at Harvard Medical School and medical director of the Center for Head and Neck Cancers at Massachusetts General Hospital, discusses how common RET alterations are in thyroid cancers.
Responses Seen With Anti-PD-1 Antibody in Anaplastic Thyroid Cancer Cohort
Lori J. Wirth, MD, discussed the findings for a small cohort of patients with anaplastic thyroid cancer treated with an anti-PD-1 antibody.
Promising Data for LOXO-292 in Thyroid Cancers
Lori J. Wirth, MD, discusses the promising results seen so far with LOXO-292 in patients with thyroid cancer.
Expectations for the Treatment Landscape of Differentiated Thyroid Cancers in the Future
Lori J. Wirth, MD, discusses the role of lenvatinib in the treatment landscape of differentiated thyroid cancer and how this might evolve in the future.