April 28th 2024
During a live Community Case Forum event in partnership with the Tennessee Oncology Practice Society, Pierre Gholam, MD, examined the current state of treatment for patients with hepatocellular carcinoma, looking in particular at what data is available for those with Child-Pugh B and C status who have poorer outcomes and have limited data from prospective clinical trials.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Expert Suggests Novel Approaches To Improve CAR Therapies in ALL
September 13th 2019To improve the efficacy of chimeric antigen receptor T-cell therapies, Nirali N. Shah, MD, MHSc, suggested including new constructs that target more than 1 antigen in patients with acute lymphoblastic leukemia, during a presentation at the 2019 SOHO Annual Meeting.<br />
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Milciclib Shows Early Clinical Benefit in Previously Treated HCC
September 5th 2019An ongoing phase IIa clinical trial has demonstrated the safety and efficacy of milciclib maleate at 6 months in patients with unresectable or metastatic hepatocellular carcinoma who were resistant or intolerant to sorafenib.
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Neelapu Discusses Toxicities Associated With CAR T Cells in Large B-Cell Lymphomas
August 29th 2019In an interview with Targeted Oncology, Sattva S. Neelapu, MD, discussed the evolving role for CAR T-cell therapy in patients with B-cell lymphomas. He also highlighted the toxicities commonly associated with these therapies and how physicians can treat these AEs as they arise.
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Investigational FGFR4 Inhibitor Shows Early Signs of Activity in HCC and ICC
August 28th 2019In an interview with Targeted Oncology, Martin E. Gutierrez, MD, discussed the findings from the first-in-human phase I study investigating H3B-6527 in patients with HCC and ICC. He also highlighted the potential role for combination therapy with H3B-6527 and the next steps planned for subsequent phase II and III trials in HCC and ICC.
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Marshall Examines TKIs and Immunotherapy Agents for GI Cancers
August 24th 2019John L. Marshall, MD, spoke with a group of physicians during a Targeted Oncology live case-based peer perspectives discussion on the different classes of agents available to treat patients with gastrointestinal cancers.
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CAR T-Cell Therapy Poised to Become Routine Care in CLL
August 13th 2019The initial pilot study of CTL019 in heavily pretreated CD19-positive hematologic malignancies demonstrated the feasibility of CAR T-cell therapy in patients with CLL. A presentation at the 2019 American Society of Gene & Cell Therapy Annual Meeting reported 2 cases of chemotherapy-resistant CLL, with ongoing follow- up at 8 years showing persistence of CAR-engineered T cells and sustained remission, as determined by flow cytometry and deep sequencing of immunoglobulin H rearrangements.
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Examining Standard Radiation Treatments for the Long-Term Management of HCC
August 9th 2019The research around best radiation-based treatment options for patients with hepatocellular carcinoma are over 15 years old, but the standard of care for long-term management of the disease is still conventional chemoembolization, according to Emil I. Cohen, MD, assistant professor, Georgetown University Hospital.
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Research Shifting to Explore Combinations for Treatment of Advanced HCC, Expert Says
August 8th 2019In an interview with <em>Targeted Oncology</em>, Llovet discussed the positive results from the REACH-2 trial and how its results are shaping future combinations therapies for the treatment of patients with advanced HCC.
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Four-Year Follow-Up Data Confirm Durable Responses With CAR T-Cell Therapy in B-Cell Lymphomas
August 7th 2019In an interview with <em>Targeted Oncology</em>, Chong, a fellow at the University of Pennsylvania, discussed the 4-year follow-up data for CAR T cells in patients with DLBCL and FL. She also addressed the challenges that need to be overcome in order to give more patients access to this type of therapy.
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MRD Reported Undetectable After Liso-cel CAR T-cell Therapy in CLL
August 2nd 2019In the phase I/II TRANSCEND CLL 004 study, chimeric antigen receptor T-cell therapy lisocabtagene maraleucel led to undetectable minimal residual disease in patients with relapsed/refractory chronic lymphocytic leukemia.
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Expert Discusses Sequencing TKI Strategies in Hepatocellular Carcinoma
August 1st 2019With 5 tyrosine kinase inhibitors approved for the treatment of patients with hepatocellular carcinoma, the next step for research in this treatment paradigm is focused on identifying the appropriate sequence of these agents.
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Assessing the Role CAR T-cell Therapy Plays in Mantle Cell Lymphoma Treatment in ZUMA-2 Trial
July 31st 2019Kieron Dunleavy, MD, discussed current approaches to treating patients with MCL, highlighting peer discussions on the subject and information about the ZUMA-2 trial, in an interview with <em>Targeted Oncology</em>.
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Expert Discusses Impact of Survival Outcomes in KEYNOTE-240 Trial for Advanced HCC
July 22nd 2019In an interview with Targeted Oncology, Richard S. Finn, MD, discussed the findings from the KEYNOTE-240 trial. He says that although these results were not statistically significant, they are still clinically meaningful.
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Namodenoson Shows Promising Efficacy in Patients With Advanced HCC, Child-Pugh B7
July 19th 2019Novel agent namodenoson demonstrated tolerability in a favorable safety profile in patients with advanced hepatocellular carcinoma and severe liver dysfunction, according to the results of a randomized phase II trial.
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Neoadjuvant Radiotherapy Improves Outcomes in Patients With HCC and Portal Vein Tumor Thrombus
July 19th 2019Treatment with 3D conformal radiotherapy prior to hepatectomy significantly improved post-operative outcomes compared with surgery alone in patients with resectable hepatocellular carcinoma and portal vein tumor thrombus, according to the results of randomized study published in the <em>Journal of Clinical Oncology</em>.<br />
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H3B-6527 Demonstrates Tolerability in Phase I Trial for Patients With Advanced HCC
July 18th 2019Martin E. Gutierrez, MD, director, Drug Discovery/Phase I Unit, and co-chief and medical oncologist, Divisions of Thoracic Oncology and Gastrointestinal Oncology, John Theurer Cancer Center, Hackensack University Medical Center, discusses the early findings for H3B-6527, an FGFR4 inhibitor, as a treatment of patients with hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma
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