April 28th 2024
During a live Community Case Forum event in partnership with the Tennessee Oncology Practice Society, Pierre Gholam, MD, examined the current state of treatment for patients with hepatocellular carcinoma, looking in particular at what data is available for those with Child-Pugh B and C status who have poorer outcomes and have limited data from prospective clinical trials.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Bevacizumab Biosimilar Under Review by FDA
March 9th 2020The FDA has accepted a Biologics License Application for MYL-1402O, a proposed biosimilar to bevacizumab, according to a press release from co-developers Biocon and Mylan. The BLA is seeking approval for the biosimilar as a treatment for multiple types of cancer and the FDA has set an action date goal of December 27, 2020, for a decision on the BLA.
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Liquid Biopsy May Play a Role in Identifying Markers of Response in HCC
March 6th 2020In an interview with Targeted Oncology, Augusto Villanueva, MD, discussed the role of driver mutations in patients with HCC and how liquid biopsies may help improve the treatment landscape in this patient population.
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FDA Grants Breakthrough Device Designation to GALAD Score for Early Diagnosis of HCC
March 4th 2020The FDA has granted Breakthrough Device designation to GALAD score, a serum biomarker-based device that predicts the probability that patients with chronic liver disease will develop hepatocellular carcinoma.
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A Look Back at FDA News from February 2020
March 4th 2020In February 2020, the FDA gave indications to multiple therapies meant for treatment of solid tumor and hematologic malignancies. FDA action included 10 Priority Reviews, 2 Breakthrough Therapy designations, and 2 Fast Track designations.
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Real-World Study Shows Snapshot of a Survival Gap With Existing Therapies for Patients With HCC
February 11th 2020In the community practice setting, patients with hepatocellular carcinoma who receive systemic therapy have a poor prognosis, which reveals an unmet need for more effective treatment options, according to a real-world retrospective observational study. The study aimed to show how treatment patterns related to the overall survival of patients with HCC throughout the United States.
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A Look Back at FDA News from January 2020
February 8th 2020In January 2020, the FDA approved new treatment options in gastrointestinal stromal tumors, bladder cancer, and epithelioid sarcoma. The FDA also granted several Priority Review Designations, orphan drug designations, and a Fast Track designation, as well as a Breakthrough Therapy designation.
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Combination Atezolizumab Plus Bevacizumab Improved Quality of Life in HCC
February 4th 2020Peter R. Galle, MD, discusses the findings that came from the phase III IMbrave 150 clinical trial, which evaluated the combination of atezolizumab plus bevacizumab versus the standard of care, sorafenib, as frontline treatment of patients with unresectable hepatocellular carcinoma.
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Lenvatinib Appears Effective in Real-Life Retrospective Analysis of Advanced HCC
February 1st 2020The tyrosine kinase inhibitor lenvatinib demonstrated promising activity and safety in patients with advanced hepatocellular carcinoma in a retrospective multicenter observational analysis in Korea, according to a poster presentation at the 2020 Gastrointestinal Cancers Symposium.
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Atezolizumab/Bevacizumab Developers Submit Application to FDA for Unresectable HCC
January 27th 2020A supplemental Biologics License Application has been submitted to the FDA for the combination of atezolizumab and bevacizumab or the treatment of patients with unresectable hepatocellular carcinoma who have not received prior systemic therapy, according to a press release from Roche.
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Consistent Treatment Benefit With Ramucirumab Across Staging in HCC
January 27th 2020Better rates of overall survival were observed in patients with intermediate-stage hepatocellular carcinoma who had an elevated baseline alpha-fetoprotein level when ramucirumab was used as second-line therapy after sorafenib compared with second-line placebo. These improvements occurred irrespective of patients' Barcelona Clinic Liver Cancer stage and were based on results of a pooled analysis of the phase III REACH and REACH-2 trials
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Patients With HCC Experience Better OS With Anticancer Procedure After Lenvatinib
January 25th 2020Frontline lenvatinib followed by an anticancer procedure resulted in prolonged overall survival in patients with unresectable hepatocellular carcinoma when compared against sorafenib, according to results of a post hoc analysis of the REFLECT trial reported at the 2020 GI Cancers Symposium.
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Ipilimumab Plus Cabozantinib and Nivolumab Increased Responses in Advanced HCC
January 25th 2020The addition of ipilimumab with the combination cabozantinib and nivolumab led to higher response rates, as well as progression-free survival and overall survival in patients with advanced hepatocellular carcinoma compared with the doublet combination alone, according to a presentation at the 2020 GI Cancers Symposium, held January 23-25, in San Francisco, California.
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Lenvatinib Yields Promising Results in Unresectable HCC
January 24th 2020In an interview with Targeted Oncology, Kaoru Tsuchiya, MD, discussed the results of the real-world study of lenvatinib in patients with unresectable hepatocellular carcinoma that are being presented at the 2020 Gastrointestinal Cancers Symposium.
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Integrating a geriatric assessment into the care of older adults who are receiving cancer treatment in communi­ty oncology practices improves patient and caregiver satisfaction and encourages commu­nication about aging-related concerns, accord­ing to results of a clinical trial that enrolled 541 patients with advanced cancer.
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New Options for Overcoming Resistance to Anti-VEGF Therapy in HCC
January 16th 2020Wasif M. Saif, MD, deputy physician in chief at the Northwell Health Cancer Institute and a professor at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, shares his expert opinion on the importance of the phase III IMbrave150 trial, which evaluated a targeted therapy combination in patients with hepatocellular carcinoma.<br />
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The standard of care for some patients with intermediate-stage hepa­tocellular carcinoma may include lenvatinib if investigators further explore results from a proof-of-concept obser­vational study. The recommended treatment for intermediate-stage hepatocellular carcinoma, transarterial chemo­embolization, is unsuitable in patients with high-tumor-burden hepatocellular carcinoma, leaving a signif­icant unmet need in clinical practice for this patient subgroup.
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Telehealth Delivers Access to Care and Cutting-Edge Clinical Research to Rural Areas
January 11th 2020The present and future benefits of telehealth in oncology can be observed through Tahoe For­est Cancer Center and its affiliation with the UC Davis Cancer Center, use of other remote clinics, and participation in virtual tumor boards. Even though there are roadblocks to telehealth reaching more locations and more patients, the potential benefit warrants the time needed to get over those hurdles.
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Fisogatinib Plus CS1001 Trial Initiated for Treatment of Advanced HCC in China
January 7th 2020A phase Ib/2 clinical trial has been initiated to assess the anti-tumor activity of FGFR4 targeted therapy fisogatinib plus the anti–PD-L1 monoclonal antibody CS1001 for the treatment of patients with locally advanced or metastatic hepatocellular carcinoma.
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Experts Reflect on the Most Impactful FDA Moves of 2019
January 4th 2020The FDA granted approval to countless treatments across cancer types throughout 2019 until the end of the year, with a final approval on December 31<sup>st </sup>for the first BRCA targeted therapy in pancreatic cancer. Following the excitement for a new year of further advances, Targeted Oncology followers on Twitter shared their thoughts on some of the most impactful FDA approvals in 2019.
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Frontline Nivolumab Demonstrates Survival Benefit Over Sorafenib in Advanced HCC
December 11th 2019In an interview with Targeted Oncology, Thomas Yau, MD, discussed the findings from the phase III CheckMate trial evaluating nivolumab in patients with advanced hepatocellular carcinoma compared with standard-of-care sorafenib. He highlighted the next steps for the trial following these data, which were presented at the 2019 European Society of Medical Oncology Congress.
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Survival Benefit Confirmed in Real-Life Analysis of Second-Line Regorafenib in HCC
December 6th 2019María Varela, MD, PhD, discusses the findings from a real-life analysis to confirm the benefit of regorafenib as treatment of patients with hepatocellular carcinoma who have progressed on prior sorafenib. Regorafenib was approved by the FDA for second-line treatment in this patient population based on data from the phase III RESORCE trial.
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A Look Back at FDA News from November 2019
December 2nd 2019In November 2019, the FDA approved a number of treatments, including acalabrutinib for the treatment of chronic lymphocytic leukemia and small lymphocytic leukemia, as well as zanubrutinib for the treatment of mantle cell lymphoma. A biosimilar for pegfilgrastim was also approved under indications.
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