Considerations for Treating Locally Advanced NSCLC
Considerations for Treating Locally Advanced NSCLC
A 60-year-old Asian Woman With Unresectable, Locally Advanced NSCLC
- A 60-year-old Asian woman presents with complaints of chest pain and shortness of breath. She reports developing a persistent cough about 1 year ago, which she attributed to allergies. In the past month, she has “spit up” blood several times, which caused her to make the appointment.
- Her history includes:
- Former smoker, quit smoking at age 35 when she became pregnant
- Normal BMI, postmenopausal, no history of cardiovascular disease
- No previous cancer history
- Evaluation and follow up testing reveal
- Stage IIIA NSCLC in right bronchi: 3.5-cm tumor with pleural involvement and spread to mediastinal lymph nodes
- WHO performance status 1
- Histology: Squamous cell
- Biomarkers:
- EGFR,BRAF,ALK/ROS1negative
- PD-L1 status: 10%
- After multidisciplinary evaluation, the patient was determined not to be a candidate for surgery, and completed chemoradiotherapy:
- Carboplatin/paclitaxel doublet plus 55 Gy radiotherapy
- Achieved stable disease without progression 14 days after completing treatment
- Began treatment with durvalumab
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