The Multidisciplinary Approach to cGVHD Diagnosis

Diagnosis and Clinical Challenges

For diagnosis, the panel generally relies on clinical features rather than biopsies for typical presentations. Biopsies are pursued when:

• Presentation is atypical or differential diagnosis includes other conditions (eg, infections, drug reactions, malignancy)
• There are isolated liver abnormalities
• Diagnoses are uncertain (eg, myositis, polyarthralgias, atypical skin manifestations)

The panelists emphasized the value of multidisciplinary collaboration with dermatology, pulmonology, and ophthalmology for accurate assessment and diagnosis, particularly for:

• Lung involvement (can be insidious and requires proactive screening with PFTs)
• Ocular assessment (Schirmer test for dryness)
• Skin assessment (looking for changes that may be missed)