The Emerging Role of Genetic Testing in Colorectal Cancer
Pashtoon M. Kasi, MD, MBBS, MS, discusses how genetic testing is underutilized in colorectal cancer, despite its ability to guide treatment dosing and adjustment based on the mutations or variations within a patient.
Pashtoon M. Kasi, MD, MBBS, MS, assistant professor of oncology and senior associate consultant in the Division of Hematology/Oncology at Mayo Clinic, discusses how genetic testing is underutilized in colorectal cancer (CRC), despite its ability to guide treatment dosing and adjustment based on the mutations or variations within a patient.
In CRC, specific genes are known to metabolize 5-fluorouracil, capecitabine, or irinotecan. Historical analyses have also shown that patients do much worse in regard to toxicities when given chemotherapy if they harbor a gene abberration, but Kasi says the frequency in which this aberration appears is underestimated.
Fedratinib Shows Promise in Chronic Neutrophilic Leukemia and MDS/MPN
January 20th 2025In an interview, Andrew Kuykendall, MD, discussed fedratinib’s potential as an effective option for patients with myelodysplastic syndrome/myeloproliferative neoplasms and chronic neutrophilic leukemia.
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Enasidenib Shows Promise as Post-Transplant Maintenance in IDH2-Mutated AML
January 7th 2025Amandeep Salhotra, MD, discussed the background and findings from a pilot trial evaluating enasidenib as post-hematopoietic stem cell transplant maintenance therapy for IDH2-mutated acute myeloid leukemia treatment.
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