The Difference Between Blocking PD-1 and PD-L1 in Melanoma
Harriet Kluger, MD, associate professor of medicine (medical oncology), associate director, Hematology/Oncology Fellowship Program, Yale Cancer Center, discusses the difference between blocking PD-1 and PD-L1 in melanoma.
Clinical Pearls
Harriet Kluger, MD, associate professor of medicine (medical oncology), associate director, Hematology/Oncology Fellowship Program, Yale Cancer Center, discusses the difference between blocking PD-1 and PD-L1 in melanoma.
- The complete biology of PD-L1 is not known yet, though there is a theory that blocking it will be less toxic than blocking PD-1
- The toxicity and activity is different in PD-1 and PD-L1
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