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Opinion|Videos|April 3, 2025

Second-Line Therapy in Advanced HCC: Treatment Considerations and Evolving Options

Author(s)Richard S. Finn, MD, Amit Singal, MD

Panelists discuss how, when a patient progresses to second-line therapy, key considerations include prior treatment response, toxicity, patient comorbidities, and therapeutic goals. Lenvatinib shows potential beyond first-line treatment, offering efficacy in patients progressing on systemic therapies, with emerging data supporting its role in treatment sequencing.

Episodes in this series

2 experts in this video

EP. 1 Current Treatment Practices in Embolization-Eligible HCC

2 experts in this video

EP. 2 When to Move Beyond TACE: The Expanding Role of Systemic Therapy in Intermediate-Stage HCC

2 experts in this video

EP. 3 Navigating the Evolving First-Line Treatment Regimens in Intermediate-Stage HCC

2 experts in this video

EP. 4 Considerations for Treatment Approaches in Intermediate-Stage HCC

2 experts in this video

EP. 5 First-Line Therapy for Advanced HCC: The Role of TKIs and ICIs

2 experts in this video

EP. 6 Lenvatinib in Advanced HCC: Considerations for Monotherapy and Combination Regimens

2 experts in this video

EP. 7 Second-Line Therapy in Advanced HCC: Treatment Considerations and Evolving Options

2 experts in this video

EP. 8 The Evolving Role of Lenvatinib in the HCC Therapeutic Landscape

Video content above is prompted by the following:

What treatment considerations arise when a patient progresses and requires second-line therapy?
Discuss the potential for lenvatinib beyond first-line treatment in patients progressing on systemic therapies.

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