Results From the CELESTIAL Trial for Patients with Advanced HCC
Ghassan K. Abou-Alfa, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center, discusses results of the CELESTIAL trial. The results were clinically and statistically significant, Abou-Alfa notes.
Ghassan K. Abou-Alfa, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center, discusses results of the CELESTIAL trial. The results were clinically and statistically significant, Abou-Alfa notes.
This randomized phase III trial compared treatment with cabozantinib (Cabometyx) versus a placebo in patients with advanced hepatocellular carcinoma (HCC) who had received a prior sorafenib (Nexavar) treatment. Findings showed a median overall survival (OS) of 10.2 months in the cabozantinib arm versus 8 months in the placebo arm.
There was also a progression-free survival rate over 5 months versus 1.5 months and a response rate of 4% versus 0.4% in the cabozantinib versus placebo arms, respectively. Patients experienced grade 3 and 4 adverse events, but none were unexpected for this drug, says Abou-Alfa.
Gholam Contrasts Lenvatinib With Other Options in Child-Pugh B HCC
December 21st 2024During a Case-Based Roundtable® event, Pierre Gholam, MD, discussed how post hoc and real-world analyses build upon the limited available trial data for treating patients with unresectable hepatocellular carcinoma with Child-Pugh B status.
Read More
Advancing Neoadjuvant Therapy for HER2+ Breast Cancer Through ctDNA Monitoring
December 19th 2024In an interview with Targeted Oncology, Adrienne Waks, MD, provided insights into the significance of the findings from the DAPHNe trial and their clinical implications for patients with HER2-positive breast cancer.
Read More
FDA Grants Dostarlimab Breakthrough Therapy Designation in dMMR/MSI-H Rectal Cancer
December 16th 2024The FDA granted breakthrough therapy designation to dostarlimab for locally advanced dMMR/MSI-H rectal cancer, highlighting its 100% clinical complete response rate in a phase 2 study.
Read More
