Rationale for MEK/BRAF Combinations in Melanoma
Keith T. Flaherty, MD, professor of Medicine, Harvard Medical School, director of Clinical Research, Massachusetts General Hospital, discusses the rationale for combining agents like dabrafenib with trametinib or binimetinib with encorafenib for patients with melanoma.<br />
Keith T. Flaherty, MD, professor of Medicine, Harvard Medical School, director of Clinical Research, Massachusetts General Hospital, discusses the rationale for combining agents like dabrafenib (Tafinlar) with trametinib (Mekinist) or binimetinib (Mektovi) with encorafenib (Braftovi) for patients with melanoma.
We’ve known for a number of years that mutatedBRAFis a bonafide therapeutic target for this patient population, Flaherty explains. Approximately 45% of patients with melanoma have activating mutations in BRAF. Around 2009, vemurafenib (Zelboraf) and dabrafenib came along and proved thatBRAFmutations were therapeutic targets. Within a few years, these drugs were FDA-approved for this patient population.
Survivorship Care Promotes Evidence-Based Approaches for Quality of Life and Beyond
March 21st 2025Frank J. Penedo, PhD, explains the challenges of survivorship care for patients with cancer and how he implements programs to support patients’ emotional, physical, and practical needs.
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