Pembrolizumab Plus Chemotherapy Show Efficacy for TNBC in KEYNOTE-355
Javier Cortes, MD, PhD, discusses the data from the phase 3 KEYNOTE-355 trial of pembrolizumab and chemotherapy versus placebo and chemotherapy for previously untreated patients with locally recurrent inoperable or metastatic triple-negative breast cancer.
Javier Cortes, MD, PhD, head of Breast Cancer and Gynecological tumors in the Oncology Department at the Ramón y Cajal University Hospital, discusses the data from the phase 3 KEYNOTE-355 trial of pembrolizumab (Keytruda) and chemotherapy versus placebo and chemotherapy for previously untreated patients with locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC).
Data from this study were presented at the 2020 American Society of Clinical Oncology Virtual Scientific Program. One of the coprimary end points of progression-free survival (PFS) in patients with PD-L1 with a Combined Positive Score (CPS) of 10 or more was met and had a hazard ratio of 0.65. Cortes says this is statistically significant and has great clinical importance. The median PFS was 5.6 months in the placebo arm compared with 9.7 months in the pembrolizumab arm.
Now that this primary end point had been achieved, the investigators are looking at the PFS data in patients with CPS of 1 or more. The PFS trend for these patients was clear, with a hazard ratio of 0.74, but the P value did not reach statistical significance at 0.0014, according to Cortes. The PFS data in the intention-to-treat population was not formally tested in KEYNOTE-355. Regarding the activity of pembrolizumab and chemotherapy, this regimen improved PFS for patients with PD-L1 expression and a CPS of 10 or more, he concluded.
Therapy Type and Site of Metastases Factor into HR+, HER2+ mBC Treatment
December 20th 2024During a Case-Based Roundtable® event, Ian Krop, MD, and participants discussed considerations affecting first- and second-line treatment of metastatic HER2-positive breast cancer in the first article of a 2-part series.
Read More
Breast Cancer Leans into the Decade of Antibody-Drug Conjugates, Experts Discuss
September 25th 2020In season 1, episode 3 of Targeted Talks, the importance of precision medicine in breast cancer, and how that vitally differs in community oncology compared with academic settings, is the topic of discussion.
Listen
Imlunestrant Improves PFS in ESR1-Mutant Advanced Breast Cancer
December 13th 2024The phase 3 EMBER-3 trial showed imlunestrant improved PFS over SOC endocrine therapy in ER-positive, HER2-negative advanced breast cancer with ESR1 mutations, though not significantly in the overall population.
Read More
