Ovarian Suppression for Younger Women With HR+ Breast Cancer
Prudence Francis, MD, discusses the SOFT trial, which examined suppression of ovarian function, and the impact it could have on the future treatment of women under 35 with HR+ breast cancer.
Clinical Pearls
Prudence Francis, MD, from the Peter MacCallum Cancer Centre in Victoria, Australia, discusses the SOFT trial, which examined suppression of ovarian function, and the impact it could have on the future treatment of women under 35 with hormone receptor-positive breast cancer.
- Younger women with HR-positive breast cancer have a higher risk of recurrence than those over 35.
- SOFT compared tamoxifen plus ovarian function suppression versus tamoxifen alone. The addition of ovarian function suppression reduced recurrence of breast cancer in higher-risk young women who did not reach menopause after chemotherapy.
- The value of adding ovarian function suppression had previously been uncertain. The findings from this study suggest that the combination could become the standard of care.
Recent Videos
Related Content
Survivorship Care Promotes Evidence-Based Approaches for Quality of Life and Beyond
March 21st 2025Article
Frank J. Penedo, PhD, explains the challenges of survivorship care for patients with cancer and how he implements programs to support patients’ emotional, physical, and practical needs.
Read More
