A 55-year old Caucasian male was admitted to the hospital with severe crampy right lower quadrant pain He had a 2-month history of constipation, general abdominal discomfort, and tiredness PMH remarkable for hyperlipidemia managed with diet and statin therapy Laboratory findings remarkable for grade 2 anemia (Hb, 9.0 g/dL) and elevated CEA (6.7 ng/mL) CT showed a non-obstructive mass in the sigmoid colon that infiltrated the full thickness of the bowel wall and involved adipose tissue Biopsy results indicated poorly differentiated invasive adenocarcinoma He opted for sigmoid colectomy and was referred to a surgeon Following surgery, R0 resection with clear margins 9 of 13 lymph nodes sampled were positive for adenocarcinoma