Primary Myelofibrosis
Primary Myelofibrosis
Case: 72-Year-Old Man Diagnosed With Primary Myelofibrosis
December 2018
- A 72-year old man presents to primary care physician with complaints of fatigue, headache, night sweats, poor appetite, and 10-15lb weight loss over past few months; report of increased abdominal pain over the last 3 months
- PMH: mild hypertension
- PE: BP 130/85; Splenomegaly ~14 cm below left costal margin
- Lab values:
- HGB: 8.9 g/dL
- Platelets: 189 x 109/L
- WBC: 27.2 x 109/L
- Serum LDH: 1500 U/L
- Serum EPO: 11.5 mU/mL
- Bone Marrow Biopsy:
- MF-2
- Circulating blasts, 1.2%
- JAK-V617F mutation, del(20q)
- Diagnosis: Primary myelofibrosis
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