Managing High-Risk Multiple Myeloma
Managing High-Risk Multiple Myeloma
- A 74-year-old woman presented with anemia, proteinuria, renal insufficiency, and pain in her right hip
- History: chronic HTN, aortic insufficiency, diabetes mellitus
- ECOG performance status, 1
- X-Ray of the pelvis showed numerous lytic lesions in the ilium and a large lesion in the right proximal femur
- MRI confirmed a 9-mm lesion in the right femoral head and numerous bilateral T1 hypointense and T2 hyperintense lesions in both iliac region
- Laboratory results:
- Hb, 10.1 g/dL
- Ca2+3.32 mmol/L
- Creatinine, 1.9 mg/dL
- Creatinine clearance, 30 mL/min
- M-protein, 1.4 g/dL
- B2M, 4.9 mcg/mL
- SFLC, kappa, 150 mg/dL
- Bone marrow biopsy, 70% plasma cells
- Molecular testing, del17p
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