How would therapeutic options change if this patient was asymptomatic?

An expert discusses alternative treatment options for a symptomatic patient with metastatic castration-resistant prostate cancer (mCRPC) and highlights the caveats around the data from the Phase 3 ALSYMPCA study of radium-223, including its conduct in an era prior to the introduction of abiraterone (ABI) and enzalutamide (ENZA).

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EP: 1.Case presentation: Patient with metastatic CRPC after ARPI and docetaxel for localized PC

EP: 2.Therapeutic options for a patient with mCRPC after ADT + docetaxel

EP: 3.PEACE-3 study of enzalutamide + Ra-223 for ARPI-naïve mCRPC: Design and objectives

EP: 4.PEACE-3 Study Results: Study Population & Disposition

EP: 5.PEACE-3 Study Results: Efficacy

EP: 6.PEACE-3 Study Results: Safety

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EP: 7.How would therapeutic options change if this patient was asymptomatic?

EP: 8.Protecting bone health for patients receiving Ra-223 + ARPI combination

EP: 9.Ongoing studies of Ra-223–based combinations

EP: 10.Ongoing studies of Ra- 223–based combinations

• What if this patient was symptomatic? What other options might you consider?
• What are the caveats around data from the phase 3 ALSYMPCA study of Ra-223 for metastatic castration-resistant prostate cancer (mCRPC)? (eg, conducted in era before introduction of ABI and ENZA)

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