KRAS-Mutated Metastatic CRC
KRAS-Mutated Metastatic CRC
Case: A 38-year Old Woman WithKRAS-Mutated mCRC
Initial presentation
- A 38-year old woman was referred to gastroenterology after experiencing several bouts of bloody diarrhea
- PMH: unremarkable
- PE: unremarkable
Clinical workup
- Colonoscopy: suspicious sigmoid mass, partial obstruction
- Biopsy: poorly differentiated adenocarcinoma
- Imaging: CT scan of the chest/abdomen/pelvis revealed multiple small bilateral liver metastases
- Molecular testing on tissue biopsy:
- Positive forKRASexon 2 codon 12 mutation
- Negative forNRAS,BRAF
- Microsatellite-stable
- Diagnosis: stage IV colorectal cancer
- ECOG PS 0
Treatment
- She underwent laparoscopic sigmoid resection
- She was initiated on treatment with FOLFOX + bevacizumab; well-tolerated
- Follow-up imaging at 3 and 6 months showed a partial response
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