EGFR Mutations in Patients With Lung Cancer
Barbara J. Gitlitz, MD, associate professor of clinical medicine, Keck Medicine, University of Southern California, discusses EGFR mutations in patients with lung cancer.
Gitlitz's case study highlights the exon 20 insertion, which is the third most common EGFR mutation. The first most common mutation is exon 19, and the second is the exon 20 mutation. Patients present with this exon 20 insertion, and they are resistant to the common EGFR tyrosine kinase inhibitor (TKI).
She stresses the importance of looking at the resistant mutation because while it still drives the cancer, the first and second generation EGFR inhibitors are not strong enough to inhibit the target.
Barbara J. Gitlitz, MD, associate professor of clinical medicine, Keck Medicine, University of Southern California, discusses EGFR mutations in patients with lung cancer.
Gholam Contrasts Lenvatinib With Other Options in Child-Pugh B HCC
December 21st 2024During a Case-Based Roundtable® event, Pierre Gholam, MD, discussed how post hoc and real-world analyses build upon the limited available trial data for treating patients with unresectable hepatocellular carcinoma with Child-Pugh B status.
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