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Beyond the Basics – Lower-Risk Myelodysplastic Syndromes

COMMANDS Study Update: Luspatercept vs. Epoetin Alfa in 1L Treatment

Video content above is prompted by the following:

Please discuss the updated data from the COMMANDS study presented at ASCO 2024.

What is the importance of the outcome data for luspatercept vs epoetin alfa in 1L treatment? (

Videos

Saeed Sadeghi, MD, discusses a case of lower-risk myelodysplastic syndromes (LR-MDS), focusing on the mechanisms of action for luspatercept vs epoetin alfa, insights from the COMMANDS study, real-world data on treatment outcomes, health care resource utilization, and future directions in anemia management within this patient population.

Saeed Sadeghi, MD, discusses the differing mechanisms of action between luspatercept and epoetin alfa, highlighting how these differences may correlate with clinical benefits for patients with lower-risk myelodysplastic syndromes (LR-MDS).

Mechanism of Action: Luspatercept vs Epoetin Alfa in LR-MDS

Saeed Sadeghi, MD, discusses the updated data from the COMMANDS study presented at ASCO 2024, emphasizing the significance of outcome data comparing luspatercept to epoetin alfa in first-line (1L) treatment for lower-risk myelodysplastic syndromes (LR-MDS).

Saeed Sadeghi, MD, reviews real-world data on luspatercept, discussing treatment patterns and outcomes, including transfusion burden, hemoglobin increase, and other key baseline data that may differ from registrational studies in the context of managing lower-risk myelodysplastic syndromes (LR-MDS).

Real-World Data on Luspatercept in LR-MDS

Saeed Sadeghi, MD, discusses the impact of health care resource utilization on treatment decisions and quality of life for patients with myelodysplastic syndromes (MDS), highlighting real-world data presented at SOHO that compares the resource utilization of U.S. patients treated with luspatercept versus erythropoiesis-stimulating agents (ESAs).

Health Care Resource Utilization: Luspatercept vs ESAs in MDS

Saeed Sadeghi, MD, shares his current approach to treating anemia in lower-risk myelodysplastic syndromes (LR-MDS), detailing when to choose erythropoiesis-stimulating agents (ESAs) for first-line treatment, conditions for switching therapies, and factors influencing the decision to use luspatercept as a first-line option, including considerations for dose escalation.

Current Approach to Treating Anemia in LR-MDS

Saeed Sadeghi, MD, explores the future treatment landscape for anemia in lower-risk myelodysplastic syndromes (LR-MDS), discussing the impact of emerging therapies on erythropoietin-stimulating agents (ESAs), identifying unmet needs in anemia management, and sharing clinical insights for community oncologists.

Future Perspective on Anemia Treatment in LR-MDS

COMMANDS Study Update: Luspatercept vs. Epoetin Alfa in 1L Treatment

EP: 1.Mechanism of Action: Luspatercept vs Epoetin Alfa in LR-MDS

EP: 2.COMMANDS Study Update: Luspatercept vs. Epoetin Alfa in 1L Treatment

EP: 3.Real-World Data on Luspatercept in LR-MDS

EP: 4.Health Care Resource Utilization: Luspatercept vs ESAs in MDS

EP: 5.Current Approach to Treating Anemia in LR-MDS

EP: 6.Future Perspective on Anemia Treatment in LR-MDS