Two recent data presentations have reported on the impact of baseline mutational burden on clinical outcomes for ESAs and luspatercept.
Please discuss the efficacy of ESAs in patients with very low vs. moderate low to very high IPSS-M risk groups.
Please discuss the clinical outcomes of luspatercept vs. epoetin alfa from the COMMANDS trial based on IPSS-M risk groups (low, moderate low, moderate high and high) and baseline mutational burden.
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