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Opinion|Videos|December 20, 2024

Additional Toxicities in GPRC5D-Directed Bispecifics for RRMM

Author(s)Binod Dhakal, MD, MS

Panelist discusses how, based on the patient achieving sCR with emerging oral, skin, and nail toxicities, panelist would recommend initiating supportive care, including oral hygiene protocols, topical treatments, and prophylactic nail care. These toxicities are generally less severe than those of BCMA-targeted bispecifics, which often present with more systemic CRS and neurotoxicity.

Episodes in this series

1 expert in this video

EP. 1 Patient Profile: A 72-Year-Old Man With RRMM

1 expert in this video

EP. 2 Overview of Bispecifics for R/R Multiple Myeloma

1 expert in this video

EP. 3 MonumenTAL-1: Data Updates of Talquetamab, a GPRC5D-Directed Bispecific Antibody for RRMM

1 expert in this video

EP. 4 Talquetamab Step-Up Dosing Strategies and CRS Monitoring

1 expert in this video

EP. 5 Additional Toxicities in GPRC5D-Directed Bispecifics for RRMM

1 expert in this video

EP. 6 Data and Treatment Considerations for BCMA-Directed Bispecifics in RRMM

1 expert in this video

EP. 7 The Future of Bispecific Therapy for R/R Multiple Myeloma

Video content above is prompted by the following:

After the first month of treatment, the patient achieved stringent complete response (sCR) but is experiencing the following symptoms: oral, skin, and nail toxicities.
What mitigation strategies would you initiate for this patient?
How do those toxicities compare with those of other bispecifics (ie, BCMA-directed) in this space?

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