Prevention of GVHD
Dr Yi-Bin Chen describes several prophylactic regimens commonly used to prevent GVHD following allogeneic hematopoietic stem cell transplant.
Acute vs Chronic GVHD, Incidence, and Risk Factors
Yi-Bin Chen, MD, delineates between acute and chronic GVHD and provides the incidence and risk factors associated with these diseases.
Future Directions in Systemic Treatment of HCC
Richard S. Finn, MD concludes the discussion by commenting on areas of unmet need in the care of HCC and emphasizes the potential impact of trials studying treatment combination and sequencing.
Clinical Trials of Lenvatinib Combination Therapy
A thought leader in the management of hepatocellular carcinoma provides an overview of several clinical trials of combination therapy with lenvatinib including studies of real-world evidence and potential biomarkers.
Lenvatinib Combination Therapy for Treatment of HCC
An expert hematologist-oncologist considers the potential role of combination therapy with lenvatinib for patients with hepatocellular carcinoma.
The REFLECT Study of Lenvatinib for Unresectable HCC
A key opinion leader in liver cancer reviews the study design of the REFLECT trial of lenvatinib in patients with HCC and shares key insights into its safety and efficacy data.
Defining Unresectable and Advanced HCC
Richard S. Finn, MD defines unresectable or advanced hepatocellular carcinoma by discussing venous invasion, extrahepatic spread, and progression after locoregional treatments.
An Overview of Hepatocellular Carcinoma
An expert in hematology-oncology, Richard S. Finn, MD, provides an overview of hepatocellular carcinoma by discussing its prevalence, patient risk factors, and overall prognosis.
Current and Future Challenges in the Treatment of CLL
Andrew Zelenetz, MD, reflects on the impact of moving agents to the frontline for treatment of chronic lymphocytic leukemia and how that impacts treatment decisions in relapsed/refractory chronic lymphocytic leukemia.
What is the Role of PI3K Inhibitors in the Treatment of CLL?
Andrew Zelenetz, MD, offers guidance on how PI3Ki (phosphoinositide 3-kinase inhibitors) fit into the treatment landscape of chronic lymphocytic leukemia.
Management of Idelalisib Associated Diarrhea
Andrew Zelenetz, MD, offers tips for management of idelalisib-associated diarrhea during treatment for chronic lymphocytic leukemia.
Idelalisib + Rituximab in Previously Treated CLL Patients
Review of a phase III trial of idelalisib + rituximab in previously treated patients with chronic lymphocytic leukemia (CLL).
Change in Therapy for CLL Due to Development of Atrial Fibrillation
Patient is switched for treatment of chronic lymphocytic leukemia from ibrutinib to idelalisib + rituximab due to development of atrial fibrillation.
First-line Treatment Options in CLL
A key opinion leader highlights alternative treatment options to ibrutinib in the first-line setting for chronic lymphocytic leukemia.
A 77-Year-Old Man with Chronic Lymphocytic Leukemia
Andrew Zelenetz, MD, outlines the case of a 77-year-old man with chronic lymphocytic leukemia.
The Future of Therapy for Advanced RCC
Robert J. Motzer, MD, shares his insights on the future of treatment for advanced renal cell carcinoma.
Updates on CLEAR from ASCO 2021
Dr Motzer discusses data from the CLEAR trial that were presented at ASCO 2021.
Impact of the CLEAR Trial on Clinical Practice
An expert explains the impact of the CLEAR trial on clinical practice and reviews NCCN guidelines for the management of advanced renal cell carcinoma.
Key Efficacy and Safety Findings from the CLEAR Trial
Dr Robert J. Motzer introduces data from the phase 3 CLEAR trial, which investigated lenvatinib plus pembrolizumab or everolimus for the treatment of advanced renal cell carcinoma.
Current Therapies for Advanced RCC: Options and Challenges
Robert J. Motzer, MD, gives a background on the current first-line therapy options for advanced renal cell carcinoma, including challenges and unmet needs.
Ongoing Challenges and Unmet Needs in CLL
A thought leader in hematology oncology highlights therapies currently in development for the management of CLL and provides closing remarks on unmet needs regarding patients who are double-refractory.
Monitoring and Managing Adverse Effects of CLL Therapy
Jeff Sharman, MD, shares insight into best practices for monitoring and managing adverse effects of treatment in chronic lymphocytic leukemia including elevated liver function tests, diarrhea, and pneumocystis pneumonia.
Second-Line Treatment Options for Relapsed CLL
An expert in the management of chronic lymphocytic leukemia discusses how patient- and disease-related factors influence treatment decisions after relapse.
Frontline Management of Chronic Lymphocytic Leukemia
A key opinion leader in hematology oncology provides an overview of treatment options for patients with newly diagnosed CLL and discusses factors to consider when monitoring patients for disease relapse.
Case Overview: A 73-Year-Old Woman With CLL
Jeff Sharman, MD, reviews the initial presentation, clinical workup, and treatment of the case of a 73-year-old woman with chronic lymphocytic leukemia and shares insight into the patient’s prognosis and risk stratification.
Future of PI3K Inhibitors in RR FL and MZL
Expert hematologist/oncologists provide thoughts on the potential role of PI3K inhibitors in managing R/R FL and MZL, as well as other diseases.
Emerging Combinations and Novel Agents for RR FL and MZL
Ian W. Flinn, MD, PhD, and Jason M. Melear, MD, discuss the role of PI3K inhibitor combination therapy and novel agents on the horizon for the treatment of R/R FL and MZL.
Case 3: Disease Progression and Transformation in ET
Stephen Oh, MD, PhD, discusses the nuances of identifying disease progression vs transformation in patients with essential thrombocythemia.
Case 3: Front Line Therapy Options in ET
Experts in essential thrombocythemia review first line treatment options.
Case 3: Molecular Profile and Initiation of Therapy in ET
Ruben Mesa, MD, and panel discuss the role of molecular profile in treatment decision-making.