Ongoing Challenges and Unmet Needs in CLL

EP: 1.Case Overview: A 73-Year-Old Woman With CLL

EP: 2.Frontline Management of Chronic Lymphocytic Leukemia

EP: 3.Second-Line Treatment Options for Relapsed CLL

EP: 4.Monitoring and Managing Adverse Effects of CLL Therapy

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EP: 5.Ongoing Challenges and Unmet Needs in CLL

Jeff Sharman, MD: In terms of the ongoing challenges for treating patients with relapsed/refractory chronic lymphocytic leukemia, there are some really encouraging developments on the horizon. We’re seeing novel BTK [Bruton tyrosine kinase] inhibitors that do not bind to cysteine 481. Consequently, these novel BTK inhibitors may work even after the covalent inhibitors have stopped working. The medication pirtobrutinib, as well as the molecule ArQule being developed by Merck & Co, Inc,may work quite well in this setting. We’re also seeing developments in chimeric antigen receptor T-cell therapy for these patients.

There’s an unmet medical need for patients who are double-refractory, or patients who’ve had both a BTK and a BCL2 inhibitor. As highlighted by this case, not everybody is an easy candidate for a venetoclax [Venclexta]–based therapy. That third- or second-line BCL2-challenged patient represents an unmet medical need, and 1 where we’re going to see additional developments in the near future.

This transcript has been edited for clarity.