Adjuvant Dabrafenib/Trametinib Combo Induces Relapse-Free Survival Rate of 58% in BRAF+ Melanoma
September 13th 2017After a median follow-up of 2.8 years, the 3-year relapse-free survival rate in patients with <em>BRAF</em>-mutant stage III melanoma who were treated with adjuvant dabrafenib and trametinib was 58% compared with 39% for placebo, according to findings from the phase III COMBI-AD study.
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Enhanced Surveillance Post-Surgery Not Associated With Longer Survival in NSCLC
September 12th 2017There was no overall survival improvement seen by expanding surveillance from chest x-ray to follow-up with PET-CT scan after surgery for patients with early-stage non–small cell lung cancer, according to data reported during the 2017 ESMO Congress.
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Nab-Paclitaxel Demonstrates Efficacy Alone and With Durvalumab in NSCLC
September 12th 2017According to findings presented at the 2017 ESMO Congress, nab-paclitaxel monotherapy demonstrated efficacy in patients with pretreated advanced nonsquamous non–small cell lung cancer that is not improved by the addition of CC-486.
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Continuous Nivolumab Treatment Leads to Improved PFS in Pretreated NSCLC
September 12th 2017In patients with previously treated advanced non-small cell lung cancer, <sup> </sup>superior progression-free survival was induced with continuous treatment with nivolumab until disease progression compared with a 1-year fixed duration treatment.
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Mature OS Results Favor Pembrolizumab Versus Chemotherapy for Patients With Advanced Bladder Cancer
September 12th 2017Median overall survival findings from treatment with pembrolizumab (Keytruda) were significantly longer compared with chemotherapy in patients with recurrent, advanced urothelial carcinoma, according to mature results from the phase III KEYNOTE-045 study.
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Significance of the Phase III FLAURA Study in EGFR+ NSCLC
September 11th 2017Joshua Bauml, MD, assistant professor, Perelman School of Medicine, University of Pennsylvania, discusses the randomized phase III FLAURA study of frontline osimertinib (Tagrisso) in patients with EGFR-mutant non-small cell lung cancer.
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Abemaciclib Added to Aromatase Inhibitors Allows for PFS Boost in HR+/HER2- Breast Cancer
September 11th 2017When abemaciclib was added to a non-steroidal aromatase inhibitor in treatment-naive patients with HER2-negative, HR-positive advanced breast cancer, the combination reduced the risk of progression of disease or death by 46% compared with either anastrozole or letrozole alone, according to findings from the phase III MONARCH 3 trial.
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An Update on Avelumab as Monotherapy for Urothelial Carcinoma
September 11th 2017Andrea Apolo, MD, medical oncologist at the National Cancer Institute and chief of the bladder cancer section of the Genitourinary Malignancies Branch, discusses the recent updates presented at the 2017 ESMO Annual Congress regarding avelumab (Bavencio) monotherapy for patients with urothelial carcinoma.
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Atezolizumab/Bevacizumab Combo Leads to Improved PFS in Kidney Cancer
September 11th 2017The combination of atezolizumab (Tecentriq) and bevacizumab (Avastin) demonstrated greater progression-free survival in patients with untreated metatatic renal cell carcinoma compared with standard sunitinib (Sutent), according to findings presented at the 2017 ESMO Congress held in Madrid, Spain.
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Avelumab Treatment in Patients With Metastatic Merkel Cell Carcinoma
September 10th 2017Celeste Lebbé, MD, from the Hôpital Saint Louis, in Paris, France, discusses avelumab treatment in chemotherapy-naive patients with distant metastatic Merkel cell carcinoma during the 2017 ESMO Annual Congress.
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Epacadostat/Pembrolizumab Combo Demonstrates Promising Activity in Advanced Melanoma
September 10th 2017In findings reported at the 2017 ESMO Annual congress in Madrid, a majority of patients with advanced melanoma responded to the combination of pembrolizumab (Keytruda) and the investigational IDO1 inhibitor epacadostat.
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Priming Immune System Before Nivolumab Improves Response in Metastatic TNBC
September 10th 2017In patients with metastatic triple negative breast cancer, turning a nonimmunogenic (“cold”) tumor into an immunogenic (“hot”) tumor appears to be feasible, thereby improving sensitivity to immune therapy with nivolumab.
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PFS Benefit in NSCLC Immunotherapy Predicted With Liquid Biopsy for Mutation Burden
September 10th 2017According to a retrospective analysis of a randomized study presented at the 2017 ESMO Congress, a liquid biopsy that measures tumor mutational burden showed promise for predicting benefit in patients with non–small cell lung cancer treated with a checkpoint inhibitor.
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Binimetinib/Encorafenib Combo Superior to Single-Agent Therapy in BRAF+ Melanoma
September 9th 2017For patients with <em>BRAF</em>-mutant advanced melanoma, the BRAF inhibitor encorafenib combined with the MEK inhibitor binimetinib demonstrated significant improvements in progression-free survival (PFS) compared with single-agent vemurafenib or encorafenib, according to updated findings from the phase III COLUMBUS trial presented at the 2017 ESMO Congress.
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Durvalumab a Promising Option for Patients With Locally Advanced Lung Cancer
September 9th 2017Treatment with the PD-L1 inhibitor durvalumab (Imfinzi) improved median PFS by 11.2 months compared with placebo for patients with locally advanced, unresectable stage III non–small cell lung cancer who had not progressed following chemoradiotherapy, according to phase III results from the PACIFIC trial presented at the 2017 ESMO Congress.
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Results of Phase III FLAURA Study Show Benefit of Frontline Osimertinib in EGFR+ NSCLC
September 9th 2017In results from the phase III FLAURA study of frontline osimertinib (Tagrisso) in patients with <em>EGFR</em>-mutant non–small cell lung cancer, osimertinib demonstrated a progression-free survival rate of 18.9 months (95% CI, 12.5-21.4), which was significantly improved over standard therapy.
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Dr. Luke Discusses the Combination of Epacadostat and Pembrolizumab in Melanoma
September 9th 2017Jason J. Luke, MD, assistant professor of Medicine, The University of Chicago Medicine, discusses the combination of epacadostat and pembrolizumab (Keytruda) for the treatment of melanoma during the 2017 ESMO Annual Congress.
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Alectinib Demonstrates Promising Efficacy for ALK+ NSCLC With CNS Brain Metastases
September 9th 2017According to findings from the phase III ALUR and ALEX studies announced ahead of the 2017 ESMO Congress,<sup> </sup>Alectinib demonstrated promising efficacy for patients with <em>ALK</em>-translocated non–small cell lung cancer with central nervous system metastases in both the first- and second-line setting.
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Taselisib/Letrozole Combo Active in ER+/HER2- Early Breast Cancer
September 8th 2017The combination of taselisib and standard letrozole improved the objective response rate compared to letrozole with a placebo in postmenopausal women with estrogen receptor-positive and HER2-negative early breast cancer, according to findings from the LORELEI study presented at the 2017 ESMO Congress in Madrid, Spain.
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Rucaparib Highly Effective as Maintenance Therapy in Ovarian Cancer Subtypes
September 8th 2017The PARP inhibitor Rucaparib (Rubraca) improved median progression-free survival by 11.2 months compared with placebo as a maintenance treatment for patients with <em>BRCA</em>-mutant platinum-sensitive ovarian cancer, according to findings from the phase III ARIEL3 trial presented at the 2017 ESMO Congress.
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Toxicities Associated With Rucaparib for the Treatment of Ovarian Cancer
September 8th 2017Jonathan Ledermann, MD, professor of medical oncology in the University College London Cancer Institute and director of Cancer Research UK and UCL Cancer Trials Centre, discusses the toxicities associated with rucaparib (Rubraca) for the treatment of ovarian cancer.
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Late-Breaking Abstracts at ESMO Could Potentially Change Lung Cancer Practice
September 7th 2017The 2017 ESMO Annual Congress, taking place September 8 to 12 in Madrid, Spain, will feature several late-breaking abstracts that are poised to change the future of treatment for patients with lung cancer, pending their results, including the phase III PACIFIC and FLAURA studies.
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Epacadostat/Pembrolizumab a Promising, Timely Combo for Melanoma, Expert Says
September 7th 2017Omid Hamid, MD, shares the top melanoma abstracts to look out for at the 2017 ESMO Annual Congress, which is taking place September 8 to 12 in Madrid, Spain, as well as some background on the promising phase I/II results he will be presenting for the combination of epacadostat plus pembrolizumab in patients with advanced melanoma.
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The challenge of precision medicine in metastatic breast cancer is to develop well-tolerated therapies based on key actionable, accessible, and validated biomarkers, said Francisco J. Esteva, MD, PhD, during an explanation of the current understanding of the molecular landscape of metastatic breast cancer at the <em>16th Annual </em>International Congress on the Future of Breast Cancer East.
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Improving Responses, Minimizing Toxicity Goal of Trastuzumab Combinations in HER2+ Breast Cancer
July 22nd 2017In the neoadjuvant and adjuvant settings of treating patients with HER2-positive breast cancer, trastuzumab (Herceptin) remains a standard of care. The question has become whether combination regimens with additional HER2-directed therapies or alternative therapies could improve responses in this patient population without added toxicities, according to Sara M. Tolaney, MD, MPH.
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Pegram Highlights a New Renaissance of Research in HER2-Positive Metastatic Breast Cancer
July 21st 2017Mark Pegram, MD, shares some of the most recent developments in the HER2-positive metastatic breast cancer space, the research currently ongoing, and why it is such an exciting time for the field.
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Age is Not All-Telling When Treating Older Adults With Breast Cancer, Expert Says
July 21st 2017In an interview with <em>Targeted Oncology, </em>Arti Hurria, MD, shares the treatment considerations she makes when treating older patients with breast cancer, the unique challenges that come with treating this patient population, and the exciting future she envisions for this space.
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