T-DM1 in Previously Treated HER2+ Metastatic Breast Cancer
September 12th 2013An analysis of the T-PAS expanded access study of T-DM1 in previously treated HER2+ metastatic breast cancer confirmed existing information on the safety of the combination, and observed significant clinical activity in a patient population that averaged seven prior therapies.
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An Expanded Access Study of T-DM1 in Previously Treated HER2-Positive Metastatic Breast Cancer
September 12th 2013Denise A. Yardley, MD, Senior Investigator, Sarah Cannon Research Institute, discusses an expanded access study of T-DM1 in previously treated HER2-positive metastatic breast cancer.
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Using the Angiogenesis Inhibitor Pazopanib to Treat Ovarian Cancer
June 2nd 2013Carol Aghajanian, MD, from the Memorial Sloan-Kettering Cancer Center, discusses a phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer.
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Evidence for Combining Anti-HER2 Therapies
March 14th 2013Approximately 20% of human breast cancers are characterized by overexpression of the HER2 receptor tyrosine kinase molecule. Multiple anitbodies have been designed to specifically target HER2, and each is able to target the molecule at a different epitope.
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The Future of Antiangiogenic Drugs Hinges on Identification of Biomarkers
March 12th 2013So far, there are no conclusive biomarkers to help identify subsets of patients who would benefit from antiangiogenic therapies, creating a barrier to the use of such treatments, Rugo said in her MBCC abstract.
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