September 20th 2024
The approval of amivantamab plus carboplatin and pemetrexed is supported by data from the phase 3 MARIPOSA-2 trial.
42nd Annual CFS: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
Register Now!
Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
View More
Annual Hawaii Cancer Conference
January 25-26, 2025
Register Now!
41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
View More
Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
View More
Differentiating Adverse Events for Antibody-Drug Conjugates Across Solid Tumor Management
View More
Entrectinib Induces Responses Across Multiple Tumor Types
October 22nd 2018Among patients with advanced solid tumors associated with <em>NTRK</em> gene fusions, more than half had responses to the small-molecule inhibitor entrectinib, according to an integrated analysis of 3 clinical trials presented at the 2018 ESMO Annual Congress.
Read More
Larotrectinib Induces 80% ORR in Advanced NTRK+ Solid Tumors
October 22nd 2018Larotrectinib induced an objective response rate of 80% in patients with advanced solid tumors who harbored <em>NTRK </em>gene fusions, according to results pooled from 3 small trials of the TRK inhibitor. Results were presented during the 2018 ESMO Congress.
Read More
Presence of MET, EGFR C797S Mutations Linked With Osimertinib Resistance in NSCLC
October 20th 2018Patients with <em>EGFR</em>-mutant non–small cell lung cancer who had <em>MET</em> amplification and <em>EGFR</em> C797S mutations were most likely to have resistance to first-line treatment with osimertinib (Tagrisso), according to preliminary findings presented at the 2018 ESMO Congress.
Read More
CMS Tackles Drug Prices, But What Does This Mean for Patient Care Access?
October 19th 2018Rising prescription drug prices continue to add to the burden of paying for quality healthcare. In an effort to confront such costs, the Centers for Medicare & Medicaid Services has rescinded a prohibition on step therapy for Medicare Advantage plans. But some contend such a policy will reduce patient access to optimal medication.
Read More
Tumor Mutational Burden Arises as an Actionable Biomarker in NSCLC
October 17th 2018Tumor mutational burden, also referred to as tumor mutational load, is a measure of the number of mutations in tumor tissue taken from a patient. Recently, several studies have been investigating the utility of TMB as a biomarker to predict response to therapy in patients with non–small cell lung cancer.
Read More
Overall Survival Not Improved With Nivolumab in SCLC
October 15th 2018According to topline findings, the phase III CheckMate-331 trial of nivolumab monotherapy for patients with small cell lung cancer who relapsed following platinum-based chemotherapy failed to meet its primary endpoint of improved overall survival compared with the standard topotecan or amrubicin.
Read More
Role of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer Oncogenic Driver Mutations
October 11th 2018Lung and bronchus cancer are the leading causes of cancer-related deaths in the United States and will be responsible for an estimated 154,050 American deaths in 2018. An estimated 234,030 new cases of lung and bronchus cancer will be diagnosed in 2018, which represents 13.5% of all new cancer diagnoses in the United States.
Read More
Update Supports Durvalumab With Chemoradiotherapy as Standard for Unresectable Stage III NSCLC
October 9th 2018Durvalumab (Imfinzi) demonstrated an improvement in overall survival compared with placebo in patients with stage III, unresectable non–small cell lung cancer who have not progressed following chemoradiotherapy, according to updated findings from the PACIFIC trial recently presented at the 19th World Conference on Lung Cancer and simultaneously published in the <em>New England Journal of Medicine</em>.
Read More
Sanborn Covers Recently Presented Trials Supporting Immunotherapy in Frontline NSCLC
October 2nd 2018Rachel Sanborn, MD, recently discussed the treatment options and considerations she makes when treating patients with non—small cell lung cancer. Sanborn, director of Thoracic Oncology, Providence Cancer Center, explained her treatment decisions based on 2 case scenarios during a <em>Targeted Oncology </em>live case-based peer perspectives presentation.
Read More
Lurbinectedin Combo Active in Chemo-Sensitive SCLC
October 1st 2018Second-line treatment with the combination of lurbinectedin (Zepsyre; PM1183) and doxorubicin demonstrated significant clinical activity in patients with small cell lung cancer, especially when excluding refractory patients, according to findings presented at the 19th World Conference on Lung Cancer in Toronto, Canada.
Read More
Frontline Dacomitinib Approved by FDA for EGFR+ NSCLC
September 28th 2018Dacomitinib has been approved by the FDA for the treatment of previously untreated patients with metastatic non–small cell lung cancer with <em>EGFR </em>exon 19 deletion or exon 21 L858R substitution mutations.
Read More
Pontchartrain Cancer Center Pushes Limits of Community Care in Southeast Louisiana
September 27th 2018Pontchartrain Cancer Center was founded in 2005 to serve an area of Louisiana that lacked the necessary resources for cancer care. This community cancer center, with 2 locations in Southeast Louisiana, accommodates any patient to walk through its doors, filling a major unmet need for the community in this rural area.
Read More
Updated Results for PACIFIC Trial Establish New Standard of Care in Lung Cancer
September 27th 2018David Spigel, MD, medical oncologist and Chief Scientific Officer at Sarah Cannon Research Institute, discusses the updated results for the PACIFIC trial, a randomized phase III trial investigating the addition of durvalumab (Imfinzi) to chemoradiation versus placebo in patients with unresectable stage III lung cancer.
Watch
Atezolizumab Demonstrates OS Improvement in SCLC
September 26th 2018Adding atezolizumab (Tecentriq) to standard carboplatin and etoposide significantly prolonged survival in patients with extensive-stage small cell lung cancer compared with the chemotherapy regimen alone in the frontline setting, according to results from the IMpower133 study.
Read More
Brigatinib Superior to Standard of Care Crizotinib in ALK+ NSCLC
September 26th 2018Adult patients with <em>ALK</em>-positive, locally advanced or metastatic non–small cell lung cancer who had not received a prior ALK inhibitor experienced a more than 50% reduction in the risk of disease progression or death with treatment with brigatinib (Alunbrig), compared with the first-line standard of care, crizotinib.
Read More
Repotrectinib Demonstrates Promising Benefit in Patients With ROS1+ NSCLC
September 26th 2018Patients with <em>ROS1</em> fusion–positive non–small cell lung cancer had clinically meaningful and durable benefit across multiple doses of repotrectinib (TPX-0005), according to interim findings from the ongoing phase I/II TRIDENT-1 study, presented at the 19th World Conference on Lung Cancer.
Read More
Promising Efficacy Seen With Poziotinib in Heavily Pretreated EGFR/HER2+ NSCLC
September 26th 2018Promising efficacy was seen with the novel targeted therapy poziotinib in patients with metastatic, heavily pretreated <em>EGFR </em>and <em>HER2 </em>exon 20 mutant non–small cell lung cancer, with a best response rate to date of 55%, according to phase II study results presented at the 19th World Conference on Lung Cancer.
Read More
Targeted Treatments Emerge for HER2 Mutations in Lung Cancer
September 20th 2018HER2 mutations have been identified as another oncogenic driver in the growing list of actionable targets in non–small cell lung cancer. Based on a mounting body of evidence on the impact of HER2 mutations in lung cancer and the growing focus on personalized medicine, the HER2 receptor has gained focus as a potential target for precision medicine treatments for patients with NSCLC.
Read More