November 22nd 2024
A phase 1 trial of α-lactalbumin vaccine for the treatment of patients with triple-negative breast cancer demonstrated safety and tolerability.
November 21st 2024
42nd Annual CFS: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
Register Now!
Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
View More
Community Oncology Connections™: Controversies and Conversations About HER2-Expressing Breast Cancer… Advances in Management from HER2-Low to Positive Disease
View More
Emerging Treatments and Evolving Paradigms in HER2-Low Breast Cancer
View More
Matching the Right Patients to the Right Therapies in TNBC: Case-Based Applications of Immune Checkpoint Inhibitors, PARP Inhibitors, and TROP2-Targeted ADCs
View More
Matching the Right Patients to the Right Therapies in TNBC: Case-Based Applications of Immune Checkpoint Inhibitors, PARP Inhibitors, and TROP2-Targeted ADCs
View More
Clinical Vignettes™: The Experts Explain How They Integrate PET Imaging into Metastatic HR+ Breast Cancer Care Settings
View More
School of Breast Oncology® Live Video Webcast: Clinical Updates from San Antonio
View More
Annual Hawaii Cancer Conference
January 25-26, 2025
Register Now!
41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
View More
42nd Annual Miami Breast Cancer Conference®
March 6 - 9, 2025
Register Now!
The Evolving Tool Box in Advanced HR+/HER2– Breast Cancer: What You Need to Know About Next-Generation SERDs, PI3K/AKT, ADCs, CDK4/6 and Beyond…
View More
Next-Generation Endocrine Therapy for ER+/HER2- Breast Cancer: Addressing Unmet Needs and Keys to Optimization in Clinical Practice
View More
Identifying Health Care Inequities in Screening, Diagnosis, and Trial Access for Breast Cancer Care: Taking Action With Evidence-Based Solutions
View More
Empowering Breast Cancer Patients with Non-Opioid Pain Management Innovations
View More
Leveraging Multidisciplinary Teams in an Evolving Treatment Landscape for Early- Stage HR+, HER2- Breast Cancer
View More
Coffee Talk™: Navigating the Impact of HER2/3, TROP2, and PARP from Early Stage to Advanced Breast Cancer Care
View More
Community Practice Connection™: Leveraging Multidisciplinary Teams in an Evolving Treatment Landscape for Early- Stage HR+, HER2- Breast Cancer
View More
How We Do It™: Defining HER2 Low on Your Pathology Reports to Make Informed Decisions in Breast Cancer Treatment
View More
Clinical Case Vignette Series™: 41st Annual Miami Breast Cancer Conference®
View More
Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
View More
24th Annual International Congress on the Future of Breast Cancer® West
July 18-19, 2025
Register Now!
24th Annual International Congress on the Future of Breast Cancer® East
July 11-12, 2025
Register Now!
Differentiating Adverse Events for Antibody-Drug Conjugates Across Solid Tumor Management
View More
Community Practice Connections™: 23rd Annual International Congress on the Future of Breast Cancer West
View More
School of Breast Oncology® (SOBO) Slide & Lecture Library
Joyce O’Shaughnessy, MD
View More
Oncology Experts Reflect on Key Takeaways from Data Presented at ASCO Annual Meeting
June 7th 2018The 2018 ASCO Annual Meeting was a great success, with over 40,000 people in attendance and over 5000 abstracts presented from June 1-5 in Chicago, Illinois. Data from several phase III trials in lung cancer were presented, with especially significant results in non–small cell lung cancer. Other big areas during this year’s meeting included breast, gastrointestinal, genitourinary, and hematologic cancers.
Read More
Activity in Relapsed Progressive TNBC With Niraparib Plus Pembrolizumab
June 6th 2018According to a preliminary prospective study presented at the 2018 ASCO Annual Meeting, half of patients with metastatic triple-negative breast cancer achieved disease control with a treatment combination of a poly polymerase inhibitor and an anti–PD-1 agent.
Read More
Both Frontline/Second-Line Benefit With Ribociclib/Fulvestrant in HR+/HER2- Breast Cancer
June 4th 2018Ribociclib in combination with fulvestrant showed an improvement in progression-free survival in postmenopausal women with hormone receptor (HR)-positive, HER2-negative advanced breast cancer; the benefit was seen both in treatment-naive patients, and in patients who had received 1 prior line of therapy, according to the results from the phase III MONALEESA-3 trial presented at the ASCO Annual Meeting.
Read More
Early Survival Results With Ipatasertib for mTNBC
June 4th 2018Ipatasertib, an oral AKT inhibitors, demonstrated early survival results as a part of a frontline combination regimen with paclitaxel for the treatment of locally advanced or metastatic triple-negative breast cancer, according to interim results of the phase II LOTUS trial.
Read More
Adjuvant Endocrine Therapy Noninferior to Chemoendocrine Therapy for Intermediate Risk Breast Cancer
June 4th 2018Adjuvant endocrine therapy alone is sufficient for patients with hormone receptor–positive, HER2-negative, node-negative early-stage breast cancer who have an intermediate risk of distant recurrence compared with endocrine therapy in combination with chemotherapy. Results of the phase III TAILORx trial presented during the 2018 ASCO Annual Meeting showed that adjuvant endocrine therapy achieved noninferiority to chemoendocrine therapy.
Read More
IMPACT Study Shows Benefit of Matched Targeted Therapies for Hard-to-Treat Cancers
June 3rd 2018According to findings of the IMPACT study discussed at the 2018 ASCO Annual Meeting, overall survival was improved with personalized therapy based on tumor molecular profiling in patients with advanced, hard-to-treat cancers.
Read More
Limited Benefit Found With Taselisib in PIK3CA-Mutant Breast Cancer
June 3rd 2018Combination taselisib plus fulvestrant demonstrated a modest progression-free survival benefit of 2 months compared with fulvestrant alone for the treatment of patients with estrogen receptor–positive, <em>PIK3CA</em>-mutant locally advanced or metastatic breast cancer.
Read More
Shorter Duration of Trastuzumab Noninferior to Standard 12 Months in Early HER2+ Breast Cancer
May 17th 2018In patients with HER2-positive early breast cancer, 6 months of adjuvant treatment with trastuzumab (Herceptin) was noninferior for disease-free survival compared with the standard 12-month schedule, according to findings from the phase III PERSEPHONE trial presented ahead of the 2018 ASCO Annual Meeting.
Read More
Analysis Identifies Distinct Characteristics of Male Breast Cancer
May 8th 2018Distinctive biologic features of breast cancer in men were determined in a recent analysis of clinical characteristics, gene expression, and 21-gene Breast Recurrence Score, which also suggested that that RS testing may have an important prognostic role for both men and women.
Read More
Expert Highlights Advancements With PARP Inhibitors in Breast Cancer
May 8th 2018While PARP inhibitors have demonstrated success in ovarian cancer previously, they are finally impacting the treatment paradigm for patients with <em>BRCA</em>-positive breast cancers, according to Nadine M. Tung, MD.
Read More
Everolimus Effective for Overcoming Endocrine Resistance in Breast Cancer
May 7th 2018Everolimus proved to be effective tool for overcoming endocrine resistance in postmenopausal women with ER-positive, HER2-negative metastatic breast cancer that have become resistant to aromatase inhibitor therapy.
Read More
A Look Back at FDA News in the Month of April
May 1st 2018The FDA approved several indications throughout the month of April 2018. A number of drugs were granted priority review and Fast Track designation. The FDA also halted all clinical trials using tazemetostat as treatment, and new initiatives were introduced to help ease the development of genetic and genomic-based tests. Check out our list of all FDA happenings from April 2018.
Read More
Larotrectinib Excites in TRK Fusion Cancers for Both Adult and Pediatric Patients
April 27th 2018When findings of larotrectinib, a pan-TRK inhibitor co-developed by Bayer and Loxo Oncology, that generated significant excitement for the treatment of both adult and pediatric patients with TRK fusion cancers, were presented during the 2017 ASCO Annual Meeting, the small molecule was lauded as a future standard of care for patients with advanced solid tumors harboring a TRK fusion.
Read More
FDA Grants Balixafortide Fast Track Designation for Treatment of Metastatic Breast Cancer Subset
April 25th 2018The immunotherapy agent balixafortide (POL6326) has been granted Fast Track designation by the FDA in combination with eribulin (Halaven) for the treatment of patients with HER2-negative metastatic breast cancer who have previously received at least 2 chemotherapeutic regimens in the metastatic setting, according to Polyphor, the manufacturer of the potent and highly selective CXCR4 antagonist.
Read More
Using Platinum Agents in Different Settings of TNBC
April 24th 2018Fabrice André, MD, PhD, professor in the Department of Medical Oncology at the Institut Gustave Roussy in Villejuif, France, addresses questions regarding the use of platinum regimens for patients with triple-negative breast cancer (TNBC). He discusses 2 platinum agents, cisplatin and carboplatin, and when it is recommended that these agents be used.
Watch
Pembrolizumab Induces Modest Benefit in ER+/HER2- Advanced Breast Cancer
April 19th 2018Pembrolizumab produced a “modest but durable” response in heavily pretreated women with PD-L1–positive, estrogen receptor-positive, HER2-negative advanced breast cancer, according to results from the KEYNOTE-028 trial which were recently published in <em>Clinical Cancer Research</em>.
Read More
Updated results of the phase III randomized OlympiAD trial, presented at the 2018 AACR Annual Meeting, suggest women with HER2-negative metastatic breast cancer associated with a germline <em>BRCA</em> mutation may have a slight survival advantage with a poly polymerase inhibitor instead of chemotherapy.
Read More
BLU-667 Demonstrates Broad Activity in RET+ Advanced Solid Tumors
April 16th 2018According to the results from a phase I study, BLU-667, a next-generation tyrosine kinase inhibitor, was well-tolerated and demonstrated clinical benefit in patients with advanced, <em>RET</em>-altered solid tumors who had progressed on previous therapies. These findings were presented April 14 to 18 at the ASCR Annual Meeting 2018 in Chicago, Illinois.
Read More
Addressing the Role of PARP Inhibitors in Different Breast Cancer Settings
April 10th 2018Jennifer Litton, MD, associate professor in the Department of Breast Medical Oncology at The University of Texas MD Anderson Cancer Center, discusses her opinion on the use of PARP inhibitors in the field of breast cancer.
Watch
Olaparib Under Review by EMA for BRCA-mutated, HER2-negative Breast Cancer
April 3rd 2018A marketing authorization application for olaparib (Lynparza) for the treatment of women with <em>BRCA</em>-mutated, HER2-negative metastatic breast cancer who previously received chemotherapy in the neoadjuvant, adjuvant, or metastatic setting has been accepted by the European Medicines Agency.
Read More
Trastuzumab Biosimilar Receives Positive Opinion From CHMP for European Approval
March 29th 2018A marketing authorization for ABP 980, a biosimilar to trastuzumab (Herceptin), has been issued a positive opinion by the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP).
Read More