October 30th 2024
The FDA is currently evaluating the application of intravesical mitomycin for low-grade intermediate-risk non–muscle-invasive bladder cancer.
October 21st 2024
Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
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Differentiating Adverse Events for Antibody-Drug Conjugates Across Solid Tumor Management
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Balar Shares Perspective on Key Findings From His Presentation at the 2019 GU Cancers Symposium
April 19th 2019Arjun V. Balar, MD, discusses key findings from updated data from the interim analysis of KEYNOTE-057, a phase II single-arm trial of pembrolizumab (Keytruda) in Bacillus Calmette-Guérin-unresponsive, high-risk nonmuscle-invasive bladder cancer, which he presented during the the 2019 Genitourinary Cancers Symposium.
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Interim Analysis of KEYNOTE-057 Shows Encouraging Antitumor Activity in NMIBC
April 13th 2019The immune checkpoint inhibitor pembrolizumab continued to demonstrate encouraging antitumor activity in an interim analysis of KEYNOTE-057, which involved a subset of 102 patients with nonmuscle-invasive bladder cancer.
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Erdafitinib Granted FDA Approval in Bladder Cancer
April 12th 2019Erdafitinib (Balversa) has been granted an accelerated approval by the FDA as a treatment for adult patients with locally advanced or metastatic bladder cancer with an <em>FGFR3</em> or <em>FGFR2</em> alteration that has progressed on platinum-containing chemotherapy, making it the first targeted agent to receive approval for metastatic bladder cancer.
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Patient Misconceptions About Clinical Trials Are a Common Source of Resistance, Expert Panel Says
April 8th 2019Before a community oncology practice considers getting involved in clinical trials research, there are many factorsto consider. Perhaps foremost is the fact that cancer clinical trials provide the evidence base for new advances in oncology.
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Despite Slow Adoption, Artificial Intelligence Pilot Programs Yield Practical Results
April 6th 2019Artificial intelligence has made inroads in many industries—banking, finance, security—but its adoption in healthcare has been lagging and real-world clinical implementation has yet to become a reality. Nonetheless, proponents say it is only a matter of time and pilot programs are starting to yield some practical results.
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Challenges Persist With CAR T-Cell Therapy in Pancreatic Cancer
April 2nd 2019The success of chimeric antigen receptor T-cell therapy observed in hematologic malignancies has not yet translated into the solid tumor setting; however, efforts continue to try to bring this new modality into the treatment paradigm for solid tumors, including pancreatic cancer.
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Enfortumab Vedotin Effective in Urothelial Carcinoma After Chemo and Immunotherapy
March 28th 2019Positive findings have been seen with a novel antibody–drug conjugate in a pivotal trial for patients with advanced or metastatic urothelial cancer who have previously been treated with immunotherapy and chemotherapy, according to an announcement from the co-manufacturers Seattle Genetics and Astellas Pharma.
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Bladder Cancer Guidelines Highlight Arrival of Immunotherapy
March 25th 2019Thomas W. Flaig, MD, discusses the latest updates to the NCCN guidelines for the treatment of patients with muscle-invasive bladder cancer. In addition, he highlights the latest approvals of checkpoint inhibitors in this patient population.
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CMS Mulls Opposition to Downsizing Part D Protected Drug Classes
March 15th 2019The healthcare community is still awaiting a response from the Centers for Medicare & Medicaid Services to the opposition of the agency’s proposal to substantially revise the Medicare Part D protected drug classes.
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Avoiding Overtreatment Saves Medicare $320M Over 3-Year Period in Older Men With Prostate Cancer
March 13th 2019Overtreating men 70 years or older with prostate cancer cost Medicare more than $1.2 billion from 2004 to 2007, according to the results of a retrospective study using the Surveillance, Epidemiology, and End Results–Medicare linked database.
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Unique Immunotherapy Combinations Provide an Optimistic Outlook in Early Urothelial Carcinoma Trials
March 11th 2019Ongoing research seeks to boost objective response rates in urothelial cancer by developing biomarkers to predict which immune checkpoint inhibitors a patient is most likely to respond to and by testing these in combination with each other and other treatment types to increase both the number and duration of responses.
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Pembrolizumab/Lenvatinib Combo Shows Activity in Small Urothelial Cancer Study
March 4th 2019The combination of lenvatinib plus pembrolizumab induced responses in a quarter of patients with urothelial carcinoma, according to the results of a small study presented at the 2019 ASCO-SITC Clinical Immuno-Oncology Symposium. The immunotherapy/targeted therapy combination also demonstrated a manageable toxicity profile.
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Bempegaldesleukin, a novel interleukin-2 therapy, showed promising activity when combined with nivolumab in patients with metastatic urothelial carcinoma who were cisplatin ineligible or refused standard therapy, according to preliminary data from the PIVOT-02 study.
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Activity Seen With Sacituzumab Govitecan in Advanced Urothelial Carcinoma
February 18th 2019According to findings from an open-label, single-arm phase I/II basket study presented during the 2019 Genitourinary Cancers Symposium, 14 of 45 patients with relapsed/refractory metastatic urothelial cancer demonstrated an objective response to sacituzumab govitecan, for an objective response rate of 31.1%.
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