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Unique Combinations to Optimize CAR T-Cell Therapy in Hematologic MalignanciesResearchers are working to optimize the outcomes associated with CAR T-cell therapy, focusing on unique combinations that may enhance T-cell fitness, improving tumor eradication and treatment outcomes.
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Using Digital Health to Promote Equity in Community Oncology PracticesDebra A. Patt, MD, PhD, MBA, discusses a study of digital health systems used at Texas Oncology locations and how it helps with remote communication between patients with cancer and clinicians.
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Immunotherapy May Lead to Abnormal Thyroid Function in Patients With CancerA comprehensive review of patients receiving pembrolizumab has found an incidence of abnormal thyroid function tests as high as 15%.
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Japanese Clinical Trial Aims to Standardize Anaplastic Thyroid Carcinoma TreatmentA Japanese research team attempted to standardize therapy for anaplastic thyroid carcinoma by assessing the feasibility and efficacy of weekly paclitaxel administration.
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Tripathy Provides an Overview of the TBCRC049 Study for HER2+ Breast CancerDebu Tripathy, MD, discusses the TBCRC049 study which evaluated tucatinib, capecitabine, and trastuzumab in the cerebral spinal fluid of patients with HER2-positive breast cancer and leptomeningeal disease.
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Adapting to the New Value-Based Payment ModelsDeepak A. Kapoor, MD, Chairman and CEO of Integrated Medical Professionals, discusses how physicians can adapt to the new value-based payment models.
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Safety Findings Appear Encouraging for REGN5458 in Relapsed/Refractory MyelomaDeepu Madduri, MD, discusses the safety findings from a first-in-human phase 1 study of REGN5458, a BCMA x CD3 bispecific monoclonal antibody, as treatment of patients with relapsed/refractory multiple myeloma.
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Unmet Needs and Future Treatment Approaches in Gastric CancerDeidre J. Cohen, MD, assistant professor, Department of Medicine, NYU Langone Medical Center, discusses unmet needs as well as future treatment approaches for patients with gastric cancer.
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Dr. Deirdre Cohen on When to Treat Gastric Cancer Patients With ImmunotherapiesDr. Deirdre Cohen talks about the increasingly big role of immunotherapies in the treatment of patients with gastric cancers.
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The Treatment of Patients With Bone Health IssuesDenise A. Yardley, MD, senior investigator, Sarah Cannon Research Institute, on the treatment of patients with breast cancer with bone health issues.
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Beating Back Breast Cancer: Study Shows Additional Therapy Effective in Node-Negative CasesDenise Yardley, MD, discusses the takeaways and next steps of an analysis of the NATALEE trial investigating ribociclib in node-negative breast cancer.
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More Endpoints Not Necessarily Merrier in NSCLC Drug TrialsThe US Food and Drug Administration (FDA) released new guidance on the use of alternative endpoints, in addition to overall survival (OS), for clinical trials of non–small cell lung cancer (NSCLC) therapies.
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Radiation Therapy for DCIS Does Not Increase Risk of Cardiovascular DiseaseWomen with DCIS treated with radiation therapy had no increased risk of cardiovascular disease compared with women in the general population or women with DCIS treated with surgery.
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Improving Radiotherapy Responses in Head and Neck Cancer With Galectin-1Dhanya K. Nambiar, PhD, Stanford University, discusses a study exploring galectin-1 in combination with radiation and immune checkpoint therapy in head and neck cancers.
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Current Treatment Landscape for Pancreatic CancerDiane Simeone, MD, director of the Pancreatic Cancer Center and associate director of Translational Research at NYU Langone’s Perlmutter Cancer Center, discusses the current state of the pancreatic cancer treatment paradigm. She says it is a very exciting time for this field as there is a large body of researchers now involved.
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Bendamustine/Rituximab as Induction Therapy in MCL<br /> Diego Villa, MD, MPH, clinical associate professor, Division of Medical Oncology, The University of British Columbia, discusses a retrospective analysis evaluating bendamustine and rituximab as induction therapy in both transplant eligible and ineligible patients with mantle cell lymphoma. <br />
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Prognostic Factors Influencing Local Control in Ewing SarcomaDimosthenis Andreou, MD, orthopedic oncologist, University Hospital Münster, discusses prognostic factors influencing local control in Ewing sarcoma.
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Dr. Dirk Arnold on Sirflox and its Effect on Liver MetastasesDirk Arnold, MD, PhD, Professor and Head Dept. Hematology and Medical Oncology at Tumor Biology Center in Freiburg, Germany, talks about sirflox and its phase III trials on whether or not it can properly add local ablative treatment to diffuse metastasization of the liver.
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Combining Targeted Therapy With Checkpoint Blockade for the Treatment of MelanomaDirk Schadendorf, MD, professor, director, and chair of the clinic for dermatology at the University Hospital Essen in Germany, discusses the combination of targeted therapy and checkpoint blockade for the treatment of melanoma.
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Findings for the Combination of Anti-TIM-3 and Anti-PD-1 in Melanoma and Lung CancerDiwakar Davar, MBBS, MSc, discusses how data from the phase I trial of TSR-022, an anti-TIM-3 monoclonal antibody, and TSR-042, an anti-PD-1 agent, impact the treatment of patients with both melanoma and lung cancer.
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The Role of In Situ Tumor VaccinationDmitriy Zamarin, MD, PhD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses the role of in situ tumor vaccination across various types of cancer.
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The Future of XMT-1536 in Ovarian Cancer and NSCLCDon Bergstrom, MD, PhD, chief medical officer, Mersana Therapeutics, discusses the future of XMT-1536 in the treatment of ovarian cancer and non-small cell lung cancer (NSCLC).
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An Overview of Ovarian Cancer ScreeningDon S. Dizon, MD, FACP, Medical Gynecologic Oncologist, Director of the Oncology Sexual Health Clinic, Massachusetts General Hospital, gives an overview of screening for ovarian cancer.
