Nagashree Seetharamu, MD, MBBS

A panelist discusses how community practitioners should monitor for immune-related adverse events when using toripalimab for recurrent/metastatic (R/M) nasopharyngeal carcinoma (NPC), establish clear patient communication about toxicities, coordinate multidisciplinary care, consider EBV monitoring, and ensure appropriate patient selection to optimize outcomes.

A panelist discusses A panelist discusses how the integration of immunotherapy with chemotherapy as first-line treatment for recurrent/metastatic (R/M) nasopharyngeal carcinoma (NPC) is transforming the treatment landscape, with data from trials such as JUPITER-02 and DIPPER demonstrating improved progression-free and overall survival outcomes, while patient selection factors including performance status, comorbidities, PD-L1 expression, and EBV status remain critical considerations for optimizing therapeutic benefit in both the metastatic setting and potentially in neoadjuvant/adjuvant approaches.

A panelist discusses how low baseline EBV levels still showed benefit from toripalimab in JUPITER-02, though EBV status influences treatment decisions and alternative markers are needed for EBV-negative cases.

A panelist discusses how toripalimab has emerged as the preferred treatment regimen for metastatic nasopharyngeal carcinoma (NPC), according to NCCN guidelines, based on improved survival outcomes in clinical trials compared with traditional chemotherapy approaches alone, though individual patient factors including performance status, prior treatments, and specific tumor characteristics must be carefully considered when personalizing the treatment strategy.

A panelist discusses how the unclear request format creates ambiguity about which case is being referenced, making it difficult to provide specific details that stand out without additional context.