Rule Discusses the Potential of Zanubrutinib in the Treatment of Mantle Cell Lymphoma
Simon Rule, MD, PhD, shares his thoughts on the FDA’s decision to grant zanubrutinib, a BTK inhibitor, priority review for the treatment of patients with mantle cell lymphoma. Should the drug be approved, it will be available for patients with MCL who have received at least 1 prior line of therapy.
Simon Rule, MD, PhD, professor of hematology, University of Plymouth, shares his thoughts on theFDA’s decision to grant zanubrutinib, a BTK inhibitor, priority review for the treatment of patients with mantle cell lymphoma(MCL). Should the drug be approved, it will be available for patients with MCL who have received at least 1 prior line of therapy.
Rule says he has used 5 BTK inhibitors now for patients with MCL, and they all work. These agents have had the same activity, in his opinion, but they have different toxicity profiles. He is pleased to potentially have another BTK inhibitor become available in this space.
Although there is excitement around having a new drug entering this space, he thinks it is possible that there will be added pressure on pricing and making these drugs more widely available for patients with MCL. In the United Kingdom, acalabrutinib (Calquence) is not available yet for these patients, as it is in the United States, but with zanubrutinib coming down the pipeline, it can only be good for patients with MCL.
Advancing Neoadjuvant Therapy for HER2+ Breast Cancer Through ctDNA Monitoring
December 19th 2024In an interview with Targeted Oncology, Adrienne Waks, MD, provided insights into the significance of the findings from the DAPHNe trial and their clinical implications for patients with HER2-positive breast cancer.
Read More
AI-Driven Deep Learning Model Shows Promise in Standardizing MDS Diagnosis
December 10th 2024In an interview, Palak Dave discussed how artificial intelligence, using deep learning to analyze bone marrow aspirate smear images, could standardize and accelerate the diagnosis of MDS vs pre-MDS conditions.
Read More
Systemic Therapy Choice Linked to Radiosurgery Outcomes in Brain Mets
December 6th 2024In an interview with Targeted OncologyT, Rupesh Kotecha, MD, discussed a study focused on how systemic therapy selection impacts outcomes in patients with brain metastases, particularly those with lung cancer.
Read More
